Sharma U, Gupta A K, Julka P K, Sharma S R, Parameswaran T, Khosla P K, Pandya A
Indian Pediatr. 1989 Sep;26(9):907-18.
The study evaluated 121 consecutive unoperated cases of retinoblastoma in children. They received radiation as the primary treatment for their ocular disease. The stage grouping was done according to Reese classification. Ninety four children had their disease evaluated by CT scan. All except one had imaged lesions in both eyes. In addition, twenty six had thickened optic nerves and twenty one showed chiasmal infiltration. Radiation field selection was based on clinical and CT imaged disease. A tumor dose of 4500c Gy in 16 to 19 fractions over 18 to 24 days was delivered by cobalt teletherapy. The target volume encompassed ora serrata anteriorly and optic chiasma posteriorly in all cases. Tumor response and patient survival was correlated with the initial stage and radiation factors utilised amongst them. Encouraging results were obtained using three field radiation technique with an open anterior field and a TDF between 75 and 90.
该研究评估了121例连续的未接受手术治疗的儿童视网膜母细胞瘤病例。他们接受放射治疗作为眼部疾病的主要治疗方法。分期分组根据里斯分类法进行。94名儿童的病情通过CT扫描进行评估。除1例外，所有患儿双眼均有影像学病变。此外，26例视神经增粗，21例显示视交叉浸润。放射野的选择基于临床和CT影像学表现的疾病情况。通过钴远距离治疗在18至24天内分16至19次给予4500c Gy的肿瘤剂量。所有病例的靶体积均包括前方的锯齿缘和后方的视交叉。肿瘤反应和患者生存率与初始分期以及其中使用的放射因素相关。采用三野放射技术，前方野开放，总剂量因子（TDF）在75至90之间，取得了令人鼓舞的结果。
