情感气质、童年期虐待及成人应激性生活事件对非临床普通成年人群抑郁症状的调节作用。
The moderator effects of affective temperaments, childhood abuse and adult stressful life events on depressive symptoms in the nonclinical general adult population.
作者信息
Nakai Yukiei, Inoue Takeshi, Chen Chong, Toda Hiroyuki, Toyomaki Atsuhito, Nakato Yasuya, Nakagawa Shin, Kitaichi Yuji, Kameyama Rie, Wakatsuki Yumi, Kitagawa Kan, Tanabe Hajime, Kusumi Ichiro
机构信息
Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan.
Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan; Department of Psychiatry, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
出版信息
J Affect Disord. 2015 Nov 15;187:203-10. doi: 10.1016/j.jad.2015.08.011. Epub 2015 Aug 28.
BACKGROUND
We recently demonstrated in the structural equation modeling that four of five affective temperaments, as measured by the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego auto-questionnaire version (TEMPS-A), are strong mediators between childhood abuse and depressive symptoms in the nonclinical general adult population. In this study, we hypothesized that affective temperaments, childhood abuse, and adult life events have moderator effects that interact with one another on depressive symptoms. The hierarchical multiple regression analysis was used to analyze this interaction model.
METHODS
The 286 participants from the nonclinical general adult population were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), Life Experiences Survey (LES), TEMPS-A, and Child Abuse and Trauma Scale (CATS). The data were analyzed using hierarchical multiple regressions with interactions.
RESULTS
Depressive temperament enhanced and hyperthymic temperament inhibited the depressogenic effects of childhood abuse, while irritable temperament enhanced and hyperthymic temperament inhibited the depressogenic effects of adult negative (stressful) life events. Adult positive life events had an inhibitory moderator effect on depressive symptoms that was increased by cyclothymic and anxious temperaments. Neglect, punishment, and total childhood abuse enhanced the effects of negative life events on depressive symptoms.
LIMITATIONS
As the subjects of this study were nonclinical, the findings should not be generalized to patients with mood disorders. In this cross-sectional study, there may be interdependence between the measured variables.
CONCLUSIONS
This study, using the hierarchical multiple regression analysis with interaction, demonstrated the positive and negative interactions between any two of affective temperaments, childhood abuse, and adult life events, and the influence on depressive symptoms in the nonclinical general adult population. Important moderator roles for affective temperaments, childhood abuse, and adult life events on depressive symptoms were suggested.
背景
我们最近在结构方程模型中证明，通过孟菲斯、比萨、巴黎和圣地亚哥自动问卷版本（TEMPS-A）测量的五种情感气质中的四种，是童年期虐待与非临床普通成年人群抑郁症状之间的强中介因素。在本研究中，我们假设情感气质、童年期虐待和成年生活事件具有相互作用的调节效应，影响抑郁症状。采用分层多元回归分析来分析这种相互作用模型。
方法
使用以下自填式问卷调查对来自非临床普通成年人群的286名参与者进行研究：患者健康问卷-9（PHQ-9）、生活经历调查（LES）、TEMPS-A和儿童虐待与创伤量表（CATS）。使用带有交互作用的分层多元回归分析数据。
结果
抑郁气质增强而环性气质抑制童年期虐待的致抑郁作用，而易怒气质增强而环性气质抑制成年期负面（应激性）生活事件的致抑郁作用。成年期积极生活事件对抑郁症状具有抑制性调节作用，这种作用在环性气质和焦虑气质的影响下增强。忽视、惩罚和童年期总虐待增强了负面生活事件对抑郁症状的影响。
局限性
由于本研究的受试者为非临床人群，研究结果不应推广至情绪障碍患者。在这项横断面研究中，所测量的变量之间可能存在相互依存关系。
结论
本研究采用带有交互作用的分层多元回归分析，证明了情感气质、童年期虐待和成年生活事件中任意两者之间的正负相互作用，以及对非临床普通成年人群抑郁症状的影响。提示了情感气质、童年期虐待和成年生活事件在抑郁症状方面的重要调节作用。
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