一种使用小牛肝焦谷氨酸氨基肽酶从蛋白质氨基末端去除焦谷氨酸的技术。 - Suppr

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A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase.

作者信息

Podell D N, Abraham G N

出版信息

Biochem Biophys Res Commun. 1978 Mar 15;81(1):176-85. doi: 10.1016/0006-291x(78)91646-7.

DOI:10.1016/0006-291x(78)91646-7

PMID:26343

Abstract

摘要

相似文献

A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase.一种使用小牛肝焦谷氨酸氨基肽酶从蛋白质氨基末端去除焦谷氨酸的技术。

Biochem Biophys Res Commun. 1978 Mar 15;81(1):176-85. doi: 10.1016/0006-291x(78)91646-7.

Pyroglutamyl N-termini of thermal polyamino acids.热聚氨基酸的焦谷氨酸N端

Biosystems. 1987;20(3):213-7. doi: 10.1016/0303-2647(87)90027-x.

Specificity of a serum peptidase hydrolyzing thyroliberin at pyroglutamyl-histidine bone.一种血清肽酶在焦谷氨酸-组氨酸键处水解促甲状腺素释放激素的特异性。

Eur J Biochem. 1981 Aug;118(1):173-6. doi: 10.1111/j.1432-1033.1981.tb05501.x.

Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues.免疫球蛋白轻链和重链的解折叠是酶促去除N端焦谷氨酰残基所必需的。

Biochim Biophys Acta. 2006 Nov;1764(11):1735-40. doi: 10.1016/j.bbapap.2006.08.018. Epub 2006 Sep 19.

Pyroglutamyl diazomethyl ketone: potent inhibitor of mammalian pyroglutamyl peptide hydrolase.焦谷氨酰重氮甲基酮：哺乳动物焦谷氨酰肽水解酶的强效抑制剂。

Biochem Biophys Res Commun. 1985 Jul 31;130(2):662-8. doi: 10.1016/0006-291x(85)90468-1.

The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.在不使蛋白质链变性的情况下从单克隆抗体中去除焦谷氨酸。

Anal Biochem. 2005 Jul 1;342(1):120-5. doi: 10.1016/j.ab.2005.04.012.

Prodrugs of peptides. IV: Bioreversible derivatization of the pyroglutamyl group by N-acylation and N-aminomethylation to effect protection against pyroglutamyl aminopeptidase.肽的前药。IV：通过N-酰化和N-氨甲基化对焦谷氨酰基进行生物可逆衍生化以实现对焦谷氨酰氨肽酶的保护。

J Pharm Sci. 1989 Feb;78(2):122-6. doi: 10.1002/jps.2600780210.

Presence of a particulate thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity in rat liver.大鼠肝脏中存在一种可降解促甲状腺激素释放激素的颗粒性焦谷氨酸氨基肽酶活性。

Neuroendocrinology. 1989 Apr;49(4):442-8. doi: 10.1159/000125150.

Pyroglutamic acid. Non-metabolic formation, function in proteins and peptides, and characteristics of the enzymes effecting its removal.焦谷氨酸。非代谢形成、在蛋白质和肽中的功能以及参与其清除的酶的特性。

Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):181-90. doi: 10.1007/BF00235695.

High-yield deblocking of amino termini of recombinant immunoglobulins with pyroglutamate aminopeptidase.用焦谷氨酸氨肽酶高效去除重组免疫球蛋白氨基末端的封闭基团。

Anal Biochem. 1998 Jul 1;260(2):183-7. doi: 10.1006/abio.1998.2690.

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EMBO J. 1985 Nov;4(11):2745-9. doi: 10.1002/j.1460-2075.1985.tb03998.x.

Insect immunity. The primary structure of the antibacterial protein attacin F and its relation to two native attacins from Hyalophora cecropia.昆虫免疫。抗菌蛋白 attacin F 的一级结构及其与 Hyalophora cecropia 两种天然 attacin 的关系。

EMBO J. 1984 Sep;3(9):2065-70. doi: 10.1002/j.1460-2075.1984.tb02092.x.

Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum.从肝素黄杆菌中分别分离出编码糖胺聚糖降解酶肝素酶II和肝素酶III的乙肝和丙肝基因，并在大肠杆菌中进行表达。

Appl Environ Microbiol. 1996 Aug;62(8):2723-34. doi: 10.1128/aem.62.8.2723-2734.1996.

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