Benuck Irwin
Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
J Clin Lipidol. 2015 Sep-Oct;9(5 Suppl):S93-S100. doi: 10.1016/j.jacl.2015.03.104. Epub 2015 Apr 9.
Screening a healthy population for future harmful diseases has the potential of reducing the risk of later morbidity and mortality with early identification and intervention. However, it is important that the screening meets acceptable standards, and the benefits of the screening outweigh risks. The recently published "Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents" (National Heart Lung Blood Institute Guidelines) carefully examined the multiple risk factors for coronary artery disease that begins in childhood but may not become problematic until years later. The evidence-based guidelines give many recommendations that are focused on identification, prevention, and intervention. Included in the guidelines are useful suggestions for improving lifestyle and food choices. In the section on lipids and lipoprotein, careful consideration was given to universal screening of children between 9 and 11 years of age with no known cardiac risk factors and again, if needed, between 17 and 21 years of age. Children with cardiac risk factors may be screened earlier. The section continues with rationale for medical management of children who are refractory to other interventions. The purpose of this article is to discuss the benefits of screening for dyslipidemia in the pediatric population and when necessary, medical management to reduce the risk for coronary artery disease. Both universal screening and early intervention in the pediatric population will identify individuals not previously recognized at risk for premature coronary artery disease and stroke and reduce the incidence of later morbidity and mortality.
对健康人群进行未来有害疾病的筛查,有可能通过早期识别和干预降低日后发病和死亡的风险。然而,筛查符合可接受的标准且筛查的益处大于风险是很重要的。最近发表的《儿童和青少年心血管健康与风险降低综合指南专家小组》(国家心肺血液研究所指南)仔细研究了始于儿童期但可能在数年之后才出现问题的冠状动脉疾病的多种风险因素。这些基于证据的指南给出了许多侧重于识别、预防和干预的建议。指南中包括了改善生活方式和食物选择的有用建议。在关于脂质和脂蛋白的章节中,仔细考虑了对9至11岁无已知心脏风险因素的儿童进行普遍筛查,如有需要,还会在17至21岁时再次进行筛查。有心脏风险因素的儿童可能会更早接受筛查。该章节接着阐述了对其他干预措施无效的儿童进行药物治疗的基本原理。本文的目的是讨论在儿科人群中筛查血脂异常的益处,以及在必要时进行药物治疗以降低冠状动脉疾病风险。在儿科人群中进行普遍筛查和早期干预,都将识别出以前未被认识到有过早患冠状动脉疾病和中风风险的个体,并降低日后发病和死亡的发生率。