Yoo Dong-Yoon, Kang Yu Sun, Kwon Eun Byul, Yoo Eun-Gyong
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Pediatrics, CHA Gumi Medical Center, Gumi, Korea.
Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):158-163. doi: 10.6065/apem.2017.22.3.158. Epub 2017 Sep 28.
The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents.
Data from 255 overweight (aged 8.7±2.0 years) and 514 normal weight (aged 8.9±1.8 years) children and adolescents were evaluated. Glucose, insulin, total cholesterol (TC), HDL-C and TG levels were measured after overnight fasting, and the TG/HDL-C ratio, non-HDL-C and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated.
The TG/HDL-C ratio was higher in overweight group compared to normal weight group (P<0.001). Among overweight children and adolescents, alanine aminotransferase (P=0.018), non-HDL-C (P<0.001), and HOMA-IR (P=0.004) were different between the TG/HDL-C ratio tertile groups. The prevalence of elevated HOMA-IR was increased with increasing TG/HDL-C ratio tertiles (P for trend=0.003). On regression analysis adjusted for age and sex, the BMI (β=0.402, P=0.001) and TG/HDL-C ratio (β=0.251, P=0.014) were independently associated with HOMA-IR (adjusted R2=0.324). The TG/HDL-C ratio of 2.0 or more showed higher sensitivity (55.6%) and specificity (72.9%), when compared to TC (≥200 mg/dL), non-HDL-C (≥145 mg/dL), and LDL-C (≥130 mg/dL) for identifying overweight children with elevated HOMA-IR.
The TG/HDL-C ratio is independently associated with insulin resistance in overweight children and adolescents, and it can be useful in identifying those at higher cardiometabolic risk.
最近有报道称，甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值是肥胖儿童和青少年心脏代谢风险的生物标志物。本研究的目的是描述韩国超重和正常体重儿童的TG/HDL-C比值及相关因素，并评估高TG/HDL-C比值是否与超重儿童和青少年的胰岛素抵抗相关。
对255名超重（年龄8.7±2.0岁）和514名正常体重（年龄8.9±1.8岁）的儿童及青少年的数据进行评估。过夜禁食后测量血糖、胰岛素、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平，并计算TG/HDL-C比值、非高密度脂蛋白胆固醇（non-HDL-C）和胰岛素抵抗稳态模型评估（HOMA-IR）。
超重组的TG/HDL-C比值高于正常体重组（P<0.001）。在超重儿童和青少年中，TG/HDL-C比值三分位数组之间的丙氨酸转氨酶（P=0.018）、非高密度脂蛋白胆固醇（P<0.001）和HOMA-IR（P=0.004）存在差异。随着TG/HDL-C比值三分位数的增加，HOMA-IR升高患病率增加（趋势P=0.003）。在对年龄和性别进行校正的回归分析中，体重指数（BMI）（β=0.402，P=0.001）和TG/HDL-C比值（β=0.251，P=0.014）与HOMA-IR独立相关（校正R2=0.
