Gómez Serrano M T, Toranzo Fernández J M, Martínez Bravo J
Rev ADM. 1989 Jan-Feb;46(1):29-35.
In the literature exist investigations made to extensive series of patients, with premalignant oral lesions or suspicious of malignancy, in which it has been employed toluidine blue (TB), to verify the trustiness of this method as a resource for support in clinical diagnosis. The results are favourable whenever is observed the correct realization of the technique that must be preceded by a careful buccal exploration and that both findings be corroborated. This work tries to exemplificate one of the techniques of TB as will as the results obtained in 28 patients, whom, for their characteristics were considered of High Risk. Emphasis is made in relation to the false positive found. Besides, is insisted in the convenience of the routine use of this resource in the odontologic private practice and at institutional level in patients over 50 years old, to whom is necessary to accomplish at a time an adequate patient history and an accurate intraoral examination, that in addition to the use of TB, will make feasible to detect more cases of malignant lesions in early stages.
在文献中，存在针对大量患有口腔癌前病变或疑似恶性病变患者的研究，其中使用了甲苯胺蓝（TB）来验证该方法作为临床诊断辅助手段的可靠性。只要观察到该技术的正确实施（必须先进行仔细的口腔检查且两项检查结果相互佐证），结果就是令人满意的。这项工作试图举例说明TB技术之一以及在28例因其特征被视为高危患者中获得的结果。重点关注了发现的假阳性情况。此外，强调了在牙科私人诊所和机构层面，对50岁以上患者常规使用该资源的便利性，对于这些患者，有必要同时完成充分的患者病史记录和准确的口腔内检查，除了使用TB之外，这将有助于在早期发现更多恶性病变病例。
