一氧化氮传感单壁碳纳米管的体内递送
In Vivo Delivery of Nitric Oxide-Sensing, Single-Walled Carbon Nanotubes.
作者信息
Iverson Nicole M, Strano Michael S, Wogan Gerald N
机构信息
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
出版信息
Curr Protoc Chem Biol. 2015 Jun 1;7(2):93-102. doi: 10.1002/9780470559277.ch140196.
Abstract
Detection of nitric oxide (NO) in vivo by single-walled carbon nanotubes (SWNT) is based on the fluorescent properties of SWNT and the ability of NO to quench the fluorescence signal. Alterations of the signal can be utilized to detect a small molecule in vivo that has not previously been possible by other assay techniques. The protocols described here explain the techniques used to prepare NO-detecting SWNTs and to administer them to mice by both intravenous and subcutaneous routes. These techniques can also be utilized with other SWNT sensors as well as non-SWNT sensors.
摘要
通过单壁碳纳米管（SWNT）在体内检测一氧化氮（NO）是基于SWNT的荧光特性以及NO淬灭荧光信号的能力。信号的变化可用于检测体内一种小分子，这是其他检测技术以前无法做到的。这里描述的方案解释了用于制备检测NO的SWNT以及通过静脉内和皮下途径将其给予小鼠的技术。这些技术也可用于其他SWNT传感器以及非SWNT传感器。
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本文引用的文献
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