Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
Department of Pharmacy, Jinan Maternity and Child Care Hospital, Jinan 250012, China.
Carbohydr Polym. 2015 Nov 20;133:391-9. doi: 10.1016/j.carbpol.2015.07.063. Epub 2015 Jul 23.
In recent years, the naturally occurring polysaccharides captured an increasing amount of attention in the field of drug/gene delivery systems owing to their outstanding propensities, including biocompatibility, biodegradability, non-immunogenicity, extremely low toxicity, and so on. Chondroitin sulfate (ChS), a member of glycosaminoglycan family, consists of repeating disaccharide units of b-1,3-linked N-acetyl galactosamine (GalNAc) and b-1,4-linked d-glucuronic acid (GlcA) with certain position(s) sulfated, which has been widely applied in nano-sized carriers. This review will focus on shared and unique properties of ChS and its latest development in drug/gene delivery systems. In detail, the application of ChS as nanocarriers will be discussed in three dimensions: self-assembly of hydrophobically modified ChS, ChS decorated nanocarriers, and some other nanocarriers based on ChS. A discussion relating to the future perspectives of ChS-based nanocarriers for drug/gene delivery is also included.
近年来，天然存在的多糖因其出色的特性，包括生物相容性、可生物降解性、非免疫原性、极低毒性等，在药物/基因传递系统领域引起了越来越多的关注。硫酸软骨素（ChS）是糖胺聚糖家族的一员，由重复的二糖单元组成，β-1,3 连接的 N-乙酰半乳糖胺（GalNAc）和β-1,4 连接的 d-葡萄糖醛酸（GlcA），某些位置硫酸化，已广泛应用于纳米载体。本综述将重点介绍 ChS 的共同和独特性质及其在药物/基因传递系统中的最新发展。详细地，将从三个方面讨论 ChS 作为纳米载体的应用：疏水改性 ChS 的自组装、ChS 修饰的纳米载体以及基于 ChS 的其他一些纳米载体。还讨论了 ChS 基纳米载体在药物/基因传递中的未来前景。
