University Paris Est, ICMPE (UMR 7182), CNRS, UPEC, F-94320 Thiais, France.
Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg Ø, Denmark.
Carbohydr Polym. 2015 Nov 20;133:473-81. doi: 10.1016/j.carbpol.2015.07.027. Epub 2015 Jul 22.
The main goal of this work was to develop a supramolecular chemistry strategy to decorate interfaces with polyethylene glycol (PEG) grafts. A series of novel bifunctionalized dextrans, bearing 40-60 PEG pending chains and 12-24 hydrophobic adamantyl groups, have been prepared by copper(I)-catalyzed azide-alkyne cycloaddition. Their binding properties toward native βCD and βCD polymers were characterized both in solution and at interface using isothermal titration microcalorimetry and surface plasmon resonance. The polymers were found to form stable layers onto neutral and positively charged βCD-polymer films pre-adsorbed on gold surfaces, due to multivalent interpolymer host-guest interactions. The thickness and stability of the layers could be tuned by varying the ratio between the degrees of substitution by PEG and adamantyl groups.
这项工作的主要目标是开发一种超分子化学策略，用聚乙二醇（PEG）接枝物修饰界面。通过铜（I）催化的叠氮-炔环加成反应，制备了一系列新型的双官能化葡聚糖，其具有 40-60 个 PEG 悬垂链和 12-24 个疏水性金刚烷基团。通过等温滴定量热法和表面等离子体共振，在溶液中和界面上对它们与天然β-CD 和β-CD 聚合物的结合特性进行了表征。由于多价的聚合物主客体相互作用，聚合物被发现能够形成稳定的层，覆盖在中性和带正电荷的β-CD-聚合物薄膜上，这些薄膜是预先吸附在金表面上的。层的厚度和稳定性可以通过改变 PEG 和金刚烷基取代度的比例来调节。
