迈向新型广谱肺炎球菌疫苗：肺炎球菌疾病预防的未来。
Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention.
作者信息
Lee Lucia H, Gu Xin-Xing, Nahm Moon H
机构信息
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
出版信息
Vaccines (Basel). 2014 Feb 14;2(1):112-28. doi: 10.3390/vaccines2010112.
Abstract
Seven-valent pneumococcal conjugate vaccine (PCV7) introduction and routine pediatric use has substantially reduced the burden of Streptococcus pneumoniae disease worldwide. However, a significant amount of disease burden, due to serotypes not contained in PCV7, still exists globally. A newly recognized serotype, 6C, was until recently, identified and reported as serotype 6A. This review summarizes the serotype epidemiology of pneumococcal disease pre- and post-introduction of PCV7, available post-marketing surveillance data following the introduction of higher valency pneumococcal vaccines (PCV10, PCV13) and future prospects for the development of new pneumococcal vaccines.
摘要
七价肺炎球菌结合疫苗（PCV7）的引入及在儿科的常规使用已大幅降低了全球范围内肺炎链球菌疾病的负担。然而，由于PCV7中未包含的血清型导致的大量疾病负担在全球仍然存在。一种新发现的血清型6C，直到最近才被识别出来，此前一直被报告为血清型6A。本综述总结了PCV7引入前后肺炎球菌疾病的血清型流行病学、更高价肺炎球菌疫苗（PCV10、PCV13）引入后的上市后监测数据以及新型肺炎球菌疫苗的未来发展前景。
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