用于HIV疫苗开发的DNA免疫接种
DNA Immunization for HIV Vaccine Development.
作者信息
Chen Yuxin, Wang Shixia, Lu Shan
机构信息
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
出版信息
Vaccines (Basel). 2014 Feb 25;2(1):138-59. doi: 10.3390/vaccines2010138.
Abstract
DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future outlook are presented. With better understanding on the potential of DNA immunization and recent progress in HIV vaccine research, it is anticipated that DNA immunization will play a more significant role in the future of HIV vaccine development.
摘要
在过去20年中，DNA疫苗接种已用于HIV疫苗研究。在载体设计、抗原优化、递送方法以及将DNA免疫作为初免-加强HIV疫苗接种策略的一部分使用方面，已经积累了丰富的经验。本文介绍了关键的历史数据和未来展望。随着对DNA免疫潜力的深入了解以及HIV疫苗研究的最新进展，预计DNA免疫将在未来HIV疫苗开发中发挥更重要的作用。
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本文引用的文献
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Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy.与 DNA 疫苗初免-蛋白疫苗加强策略中使用的特定佐剂相关的血清细胞因子谱。
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HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques.HIV/SIV DNA 疫苗与蛋白质联合使用的共免疫方案可在小鼠和猕猴中引发针对包膜的最高体液免疫反应。
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