俄罗斯一起由混合西伯利亚立克次体亚种和“候选立克次体 tarasevichiae”感染引起的蜱传斑疹伤寒致死病例。
A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" infection in Russia.
机构信息
Omsk Research Institute of Natural Focal Infections, Omsk, Russia; Omsk State Medical University, Omsk, Russia.
Omsk Research Institute of Natural Focal Infections, Omsk, Russia.
出版信息
Ticks Tick Borne Dis. 2019 Oct;10(6):101278. doi: 10.1016/j.ttbdis.2019.101278. Epub 2019 Aug 24.
North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and "Candidatus R. tarasevichiae" was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and "Candidatus R. tarasevichiae" human infection with a fatal outcome in Russia.
北亚蜱传斑疹伤寒（NATT），又称西伯利亚蜱传斑疹伤寒，是俄罗斯西伯利亚地区主要的蜱传立克次体病。最近，一名 4 岁女孩出现典型的蜱传立克次体病症状（发热、皮疹、蜱叮咬部位的焦痂、肌痛）和脑膜综合征，出现了一起致命感染。为了确定此次感染的病因，通过聚合酶链反应（PCR）和后续测序，对患者的血液和脑部样本进行了广泛的蜱传病原体和肠道病毒检测。在血液和脑部样本中均检测到了西伯利亚立克次体亚种和“候选立克次体tarasevichiae”的 DNA。通过 gltA、ompA 和 ompB 基因对西伯利亚立克次体进行了鉴定，而“候选立克次体 tarasevichiae”则通过 gltA 和 ompB 基因进行了鉴定。我们报告了在俄罗斯首例混合感染西伯利亚立克次体和“候选立克次体 tarasevichiae”并导致致命后果的人类感染病例。
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