与不同抗氨酰基转移RNA合成酶抗体相关的临床亚组及其与共存抗Ro52的关联。

Clinical subsets associated with different anti-aminoacyl transfer RNA synthetase antibodies and their association with coexisting anti-Ro52.

作者信息

Yamasaki Yoshioki, Satoh Minoru, Mizushima Machiko, Okazaki Takahiro, Nagafuchi Hiroko, Ooka Seido, Shibata Tomohiko, Nakano Hiromasa, Ogawa Hitoshi, Azuma Kohei, Maeda Akihiko, Tonooka Kumiko, Ito Hiroshi, Takakuwa Yukiko, Inoue Makoto, Mitomi Hirofumi, Kiyokawa Tomofumi, Tsuchida Kosei, Matsushita Hiromi, Mikage Hidenori, Murakami Yoshihiko, Chan Jason Y F, Ozaki Shoichi, Yamada Hidehiro

机构信息

a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .

b Department of Clinical Nursing, School of Health Sciences , University of Occupational and Environmental Health , Kitakyushu , Japan .

出版信息

Mod Rheumatol. 2016;26(3):403-9. doi: 10.3109/14397595.2015.1091155. Epub 2015 Oct 19.

DOI:10.3109/14397595.2015.1091155

PMID:26344678

Abstract

OBJECTIVE

To characterize clinical features of polymyositis/dermatomyositis (PM/DM) patients with different anti-aminoacyl transfer RNA synthetase (ARS) antibodies and their association with anti-Ro52.

METHODS

Autoantibodies in sera from 97 Japanese patients (36 PM, 56 DM, and 5 clinically amyopathic DM), who satisfied Bohan and Peter or modified Sontheimer's criteria, were characterized by immunoprecipitation and enzyme-linked immunosorbent assay. Clinical information was from medical records. Features associated with different anti-ARS and anti-Ro52 antibodies were analyzed.

RESULTS

The prevalence of anti-ARS was similar to other studies (Jo-1, 22%; EJ, 4%; OJ, 1%; PL-12, 1%), except for a high prevalence of anti-PL-7 (12%), which allowed us to characterize patients carrying this specificity. Serum creatine kinase >3000 IU/l was less common in anti-PL-7-positive patients (57%) than anti-Jo-1-positive patients (18%) (p = 0.0328) and was not found in anti-EJ-positive individuals. Interstitial lung disease was common in anti-ARS-positive patients (97%) (p < 0.0001 vs. 48% in anti-ARS-negative). Anti-Ro52 antibodies were frequently detected with anti-ARS (59%) (57% in anti-Jo-1, 67% in anti-PL-7) (vs. 21% in anti-ARS-negative, p < 0.0002). Anti-Ro52 was associated with overlap syndrome (26%) (vs. 7% in anti-Ro52-negative, p = 0.0119).

CONCLUSIONS

Patients with different anti-ARS in combination with anti-Ro52 appear to be associated with distinctive clinical subsets.

摘要

目的

描述不同抗氨酰基转移RNA合成酶（ARS）抗体的多发性肌炎/皮肌炎（PM/DM）患者的临床特征及其与抗Ro52的关联。

方法

采用免疫沉淀法和酶联免疫吸附测定法对97例符合博汉和彼得标准或改良桑特海默标准的日本患者（36例PM、56例DM和5例临床无肌病性DM）血清中的自身抗体进行特征分析。临床信息来自病历。分析与不同抗ARS和抗Ro52抗体相关的特征。

结果

抗ARS的患病率与其他研究相似（Jo-1，22%；EJ，4%；OJ，1%；PL-12，1%），但抗PL-7的患病率较高（12%），这使我们能够对具有这种特异性的患者进行特征描述。抗PL-7阳性患者血清肌酸激酶>3000 IU/l的情况（57%）比抗Jo-1阳性患者（18%）少见（p = 0.0328），抗EJ阳性个体中未发现。间质性肺病在抗ARS阳性患者中很常见（97%）（与抗ARS阴性患者的48%相比，p < 0.0001）。抗Ro52抗体常与抗ARS同时检测到（59%）（抗Jo-1中为57%，抗PL-7中为67%）（与抗ARS阴性患者的21%相比，p < 0.0002）。抗Ro52与重叠综合征相关（占26%）（与抗Ro52阴性患者的7%相比，p = 0.0119）。