Lee J Y, Lin C K, Liu N H, Gau J P
Zhonghua Yi Xue Za Zhi (Taipei). 1989 Nov;44(5):305-12.
Fine needle aspiration biopsy cytology was done in 215 lymph nodes involving cervical, submandibular, supraclavicular, axillary and inguinal regions. One hundred and forty of these were diagnosed by histopathology after excisional biopsy or surgery, including 46 cases of metastatic tumor, 57 of lymphoma (46 were non-Hodgkin's lymphoma and 11 were Hodgkin's disease), and 37 of benign lymphadenopathy. Diagnosis of metastatic malignancy was easily made by aspiration biopsy cytology with a total sensitivity of 95.7% (44/46). The diagnosis of lymphoma was less satisfactory with a total sensitivity of 82.5% (47/57). The specificity for diagnosis of benign lymphadenopathy was 97.3% (36/37) with one false positive. The concordance of cell type in aspiration biopsy cytology and histopathology was 75% (33/44) in metastatic malignancy, and 73.5% (28/38) in lymphoma. Typical Reed-Sternberg giant cells were detected in 4 of 11 cases of Hodgkin's disease by aspiration cytology. Out of the 37 cases of benign lymphadenopathy diagnosed by aspiration cytology, 7 were cases of tuberculous lymphadenitis, of which typical Langhans' giant cells were found in 2, and acid fast stain bacilli in 3 cases. There was no complication or needle tract spreading throughout the procedure. We concluded that aspiration biopsy cytology is a simple, safe, reliable, and quick diagnostic method.
对涉及颈部、颌下、锁骨上、腋窝和腹股沟区域的215个淋巴结进行了细针穿刺活检细胞学检查。其中140个在切除活检或手术后通过组织病理学诊断，包括46例转移性肿瘤、57例淋巴瘤（46例为非霍奇金淋巴瘤，11例为霍奇金病）和37例良性淋巴结病。通过穿刺活检细胞学检查很容易做出转移性恶性肿瘤的诊断，总敏感性为95.7%（44/46）。淋巴瘤的诊断不太令人满意，总敏感性为82.5%（47/57）。良性淋巴结病诊断的特异性为97.3%（36/37），有1例假阳性。穿刺活检细胞学检查与组织病理学检查的细胞类型一致性在转移性恶性肿瘤中为75%（33/44），在淋巴瘤中为73.5%（28/38）。在11例霍奇金病的穿刺细胞学检查中，4例检测到典型的里德-斯腾伯格巨细胞。在通过穿刺细胞学检查诊断的37例良性淋巴结病中，7例为结核性淋巴结炎，其中2例发现典型的朗汉斯巨细胞，3例发现抗酸染色杆菌。整个过程中没有并发症或针道播散。我们得出结论，穿刺活检细胞学检查是一种简单、安全、可靠且快速的诊断方法。
