Maheux Chad R, Alarcon Idralyn Q, Copeland Catherine R, Cameron T Stanley, Linden Anthony, Grossert J Stuart
Science and Engineering Directorate, Canada Border Services Agency, 79 Bentley Avenue, Ottawa, K2E 6T7, Ontario, Canada.
Department of Chemistry, Dalhousie University, PO Box 15000, Halifax, Nova Scotia, B3H 4R2, Canada.
Drug Test Anal. 2016 Aug;8(8):847-57. doi: 10.1002/dta.1859. Epub 2015 Sep 7.
Ethylone, a synthetic cathinone with psychoactive properties, is a designer drug which has appeared on the recreational drug market in recent years. Since 2012, illicit shipments of ethylone hydrochloride have been intercepted with increasing frequency at the Canadian border. Analysis has revealed that ethylone hydrochloride exists as two distinct polymorphs. In addition, several minor impurities were detected in some seized exhibits. In this study, the two conformational polymorphs of ethylone hydrochloride have been synthesized and fully characterized by FTIR, FT-Raman, powder XRD, GC-MS, ESI-MS/MS and NMR ((13) C CPMAS, (1) H, (13) C). The two polymorphs can be distinguished by vibrational spectroscopy, solid-state nuclear magnetic resonance spectroscopy and X-ray diffraction. The FTIR data are applied to the identification of both polymorphs of ethylone hydrochloride (mixed with methylone hydrochloride) in a laboratory submission labelled as 'Ocean Snow Ultra'. The data presented in this study will assist forensic scientists in the differentiation of the two ethylone hydrochloride polymorphs. This report, alongside our recent article on the single crystal X-ray structure of a second polymorph of this synthetic cathinone, is the first to confirm polymorphism in ethylone hydrochloride. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd.
乙酮是一种具有精神活性的合成卡西酮，是一种近年来出现在娱乐性毒品市场上的设计药物。自2012年以来，加拿大边境截获盐酸乙酮非法运输货物的频率不断增加。分析表明，盐酸乙酮以两种不同的多晶型物形式存在。此外，在一些查获的展品中检测到了几种微量杂质。在本研究中，已合成了盐酸乙酮的两种构象多晶型物，并通过傅里叶变换红外光谱（FTIR）、傅里叶变换拉曼光谱（FT-Raman）、粉末X射线衍射（XRD）、气相色谱-质谱联用（GC-MS）、电喷雾电离串联质谱（ESI-MS/MS）和核磁共振（（13）C交叉极化魔角旋转（CPMAS）、（1）H、（13）C）对其进行了全面表征。这两种多晶型物可以通过振动光谱、固态核磁共振光谱和X射线衍射来区分。FTIR数据被应用于鉴定一份标记为“海洋雪超纯”的实验室送检样品中盐酸乙酮（与盐酸甲酮混合）的两种多晶型物。本研究中呈现的数据将有助于法医科学家区分盐酸乙酮的两种多晶型物。本报告与我们最近关于这种合成卡西酮第二种多晶型物单晶X射线结构的文章一起，首次证实了盐酸乙酮的多晶型现象。© 2015加拿大边境服务局。《药物测试与分析》由约翰·威利父子有限公司出版。© 2015加拿大边境服务局。《药物测试与分析》由约翰·威利父子有限公司出版。
