丁酸梭菌和枯草芽孢杆菌益生菌可改善肠道肿瘤发生。
Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.
作者信息
Chen Zhao-Fei, Ai Luo-Yan, Wang Ji-Lin, Ren Lin-Lin, Yu Ya-Nan, Xu Jie, Chen Hao-Yan, Yu Jun, Li Min, Qin Wen-Xin, Ma Xiong, Shen Nan, Chen Ying-Xuan, Hong Jie, Fang Jing-Yuan
机构信息
Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
Department of Medicine & Therapeutics, Institute of Digestive Disease & LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
出版信息
Future Microbiol. 2015;10(9):1433-45. doi: 10.2217/fmb.15.66. Epub 2015 Sep 7.
AIMS
To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression.
MATERIALS & METHODS: The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers.
RESULTS & CONCLUSIONS: C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.
目的
研究益生菌丁酸梭菌和枯草芽孢杆菌对结直肠癌（CRC）进展的抗肿瘤作用。
材料与方法
研究了丁酸梭菌和枯草芽孢杆菌对CRC细胞的影响。用1,2 - 二甲基肼二盐酸盐（DMH）诱导的CRC雄性C57BL/6小鼠接受这两种益生菌干预，并通过比较肿瘤发生率和检测炎症及免疫相关标志物来检查抗肿瘤作用。
结果与结论
丁酸梭菌和枯草芽孢杆菌抑制CRC细胞增殖，导致细胞周期停滞并促进细胞凋亡。在体内，这两种益生菌抑制了DMH诱导的CRC的发展。其分子机制涉及减轻炎症和改善免疫稳态。这项工作为枯草芽孢杆菌和丁酸梭菌在肠道肿瘤发生中的保护作用奠定了基础。
Zotero 插件