Sang Yaodong, Zheng Kexin, Zhao Yulong, Liu Yuan, Zhu Siqiang, Xie Xiaozhou, Shang Liang, Liu Jin, Li Leping
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Transl Cancer Res. 2024 Apr 30;13(4):2043-2063. doi: 10.21037/tcr-24-316. Epub 2024 Apr 15.
With advances in gut microbiome research, it has been recognized that the gut microbiome has an important and far-reaching impact on many human diseases, including cancer. Therefore, more and more researchers are focusing on the treatment of gut flora in tumors. In this article, we present a review of the mechanisms of gut microbes in tumor immunotherapy and related studies to provide reference for further research and insights into the clinical application of gut microbes.
Between April 25, 2023, and November 25, 2023, we searched for articles published only in English between 1984 and 2023 using the databases PubMed, American Medical Association and Elsevier ScienceDirect using the keywords "gut microbiology" and "tumor" or "immunotherapy".
The gastrointestinal tract contains the largest number of microorganisms in the human body. Microorganisms are involved in regulating many physiological activities of the body. Studies have shown that gut microbes and their derivatives are involved in the occurrence and development of a variety of inflammations and tumors, and changes in their abundance and proportion affect the degree of cancer progression and sensitivity to immunotherapy. Gut microbiota-based drug research is ongoing, and some anti-tumor studies have entered the clinical trial stage.
The abundance and proportion of intestinal microorganisms influence the susceptibility of tumors to tumor immunotherapy. This article reviewed the effects and mechanisms of gut microbes on tumor immunotherapy to further explore the medical value of gut microbes in tumor immunotherapy.
随着肠道微生物组研究的进展，人们已经认识到肠道微生物组对包括癌症在内的许多人类疾病具有重要且深远的影响。因此，越来越多的研究人员将重点放在肿瘤中肠道菌群的治疗上。在本文中，我们对肠道微生物在肿瘤免疫治疗中的机制及相关研究进行综述，为进一步研究以及深入了解肠道微生物在临床应用中的情况提供参考。
在2023年4月25日至2023年11月25日期间，我们使用PubMed、美国医学协会和爱思唯尔科学Direct数据库，通过关键词“肠道微生物学”和“肿瘤”或“免疫治疗”，搜索了1984年至2023年间仅以英文发表的文章。
胃肠道是人体中微生物数量最多的部位。微生物参与调节人体的许多生理活动。研究表明，肠道微生物及其衍生物参与多种炎症和肿瘤的发生发展，其丰度和比例的变化影响癌症进展程度和对免疫治疗的敏感性。基于肠道微生物群的药物研究正在进行中，一些抗肿瘤研究已进入临床试验阶段。
肠道微生物的丰度和比例影响肿瘤对肿瘤免疫治疗的易感性。本文综述了肠道微生物对肿瘤免疫治疗的作用及机制，以进一步探索肠道微生物在肿瘤免疫治疗中的医学价值。
