Ferro M A
Department of Psychiatry and Behavioural Neurosciences,McMaster University,Hamilton,Ontario,Canada.
Epidemiol Psychiatr Sci. 2016 Oct;25(5):462-474. doi: 10.1017/S2045796015000700. Epub 2015 Sep 8.
Despite the considerable physical, emotional and social change that occurs during emerging adulthood, there is little research that examines the association between having a chronic health condition and mental disorder during this developmental period. The aims of this study were to examine the sex-specific prevalence of lifetime mental disorder in an epidemiological sample of emerging adults aged 15-30 years with and without chronic health conditions; quantify the association between chronic health conditions and mental disorder, adjusting for sociodemographic and health factors; and, examine potential moderating and mediating effects of sex, level of disability and pain.
Data come from the Canadian Community Health Survey-Mental Health. Respondents were 15-30 years of age (n = 5947) and self-reported whether they had a chronic health condition. Chronic health conditions were classified as: respiratory, musculoskeletal/connective tissue, cardiovascular, neurological and endocrine/digestive. The World Health Organization Composite International Diagnostic Interview 3.0 was used to assess the presence of mental disorder (major depressive disorder, suicidal behaviour, bipolar disorder and generalised anxiety disorder).
Lifetime prevalence of mental disorder was significantly higher for individuals with chronic health conditions compared with healthy controls. Substantial heterogeneity in the prevalence of mental disorder was found in males, but not in females. Logistic regression models adjusting for several sociodemographic and health factors showed that the individuals with chronic health conditions were at elevated risk for mental disorder. There was no evidence that the level of disability or pain moderated the associations between chronic health conditions and mental disorder. Sex was found to moderate the association between musculoskeletal/connective tissue conditions and bipolar disorder (β = 1.71, p = 0.002). Exploratory analyses suggest that the levels of disability and pain mediate the association between chronic health conditions and mental disorder.
Physical and mental comorbidity is prevalent among emerging adults and this relationship is not augmented, but may be mediated, by the level of disability or pain. Findings point to the integration and coordination of public sectors - health, education and social services - to facilitate the prevention and reduction of mental disorder among emerging adults with chronic health conditions.
尽管在成年初期会发生相当大的身体、情感和社会变化,但很少有研究探讨在这个发育阶段患有慢性健康状况与精神障碍之间的关联。本研究的目的是调查在15至30岁患有和未患有慢性健康状况的成年初期人群的流行病学样本中,终生精神障碍的性别特异性患病率;量化慢性健康状况与精神障碍之间的关联,并对社会人口学和健康因素进行调整;以及研究性别、残疾程度和疼痛的潜在调节和中介作用。
数据来自加拿大社区健康调查-心理健康。受访者年龄在15至30岁之间(n = 5947),并自我报告是否患有慢性健康状况。慢性健康状况分为:呼吸系统、肌肉骨骼/结缔组织、心血管、神经和内分泌/消化系统。使用世界卫生组织综合国际诊断访谈3.0来评估精神障碍(重度抑郁症、自杀行为、双相情感障碍和广泛性焦虑症)的存在情况。
与健康对照组相比,患有慢性健康状况的个体终生精神障碍患病率显著更高。在男性中发现精神障碍患病率存在显著异质性,但在女性中未发现。对多个社会人口学和健康因素进行调整的逻辑回归模型显示,患有慢性健康状况的个体患精神障碍的风险更高。没有证据表明残疾程度或疼痛会调节慢性健康状况与精神障碍之间的关联。发现性别会调节肌肉骨骼/结缔组织疾病与双相情感障碍之间的关联(β = 1.71,p = 0.002)。探索性分析表明,残疾程度和疼痛水平介导了慢性健康状况与精神障碍之间的关联。
身心共病在成年初期人群中很普遍,这种关系不会因残疾程度或疼痛而增强,但可能由其介导。研究结果表明,公共部门(卫生、教育和社会服务)需要整合与协调,以促进预防和减少患有慢性健康状况的成年初期人群中的精神障碍。