Qadeer Rana A, Shanahan Lilly, Ferro Mark A
Department of Clinical Epidemiology and Biostatistics, McMaster University, Canada.
Department of Psychology, University of Zürich, Switzerland.
Scand J Pain. 2017 Oct;17:30-36. doi: 10.1016/j.sjpain.2017.07.009. Epub 2017 Jul 26.
There has been a growth in the proportion of emerging adults vulnerable to pain-related sequelae of chronic health conditions (CHCs). Given the paucity of research during this important developmental period, this study investigated the association between CHCs and chronic disruptive pain among emerging adults and the extent to which psychiatric disorders moderate this association.
Data come from the 2012 Canadian Community Health Survey - Mental Health (CCHS-MH). This cross-sectional survey included 5987 participants that were 15-30 years of age and self-reported their CHCs (n=2460, 41%) and the extent to which pain impacted daily functioning using items from the Health Utilities Index Mark 3 (HUI 3). Group comparisons between respondents with CHCs and healthy controls were made using chi-square tests. Odds ratios (OR) and 95% confidence intervals (CI) were computed from ordinal logistic regression models adjusting for sociodemographic covariates. Product-term interactions between CHCs and psychiatric disorders were included in the models to explore moderating effects. All analyses were weighted to maintain representativeness of the study sample to the Canadian population.
The mean age of participants was 23.5 (SE 0.1) years and 48% were female. Compared to healthy controls, a greater proportion of participants with CHCs reported having chronic pain (20.3% vs. 4.5%, p<0.001). Among those with chronic pain, respondents with CHCs reported a greater number of activities prevented because of chronic disruptive pain (χ=222.28, p<0.001). Similarly, in logistic regression models, participants with CHCs had greater odds of reporting chronic disruptive pain (OR=4.94, 95% CI=4.08-5.99). Alcohol (β=-0.66; p=0.025) and drug abuse/dependence disorders (β=-1.24; p=0.012) were found to moderate the association between CHCs and chronic disruptive pain. Specifically, the probability of chronic disruptive pain was higher for emerging adults without CHCs and with alcohol or drug disorders; however, among participants with CHCs, probability was higher for those without these disorders.
There is a robust association between CHCs and chronic disruptive pain. The moderating effects suggest that alcohol or drug disorders are especially harmful for emerging adults without CHCs and contribute to higher levels of chronic disruptive pain; however, among those with CHCs, alcohol and illicit drugs may be used as a numbing agent to blunt chronic disruptive pain.
Findings from this study have implications for the integration and coordination of services to design strategies aimed at managing chronic disruptive pain and preventing pain-related disabilities later in life. Within the health system, healthcare providers should engage in dialogues about mental health and substance use regularly with emerging adults, be proactive in screening for psychiatric disorders, and continue to monitor the impact of pain on daily functioning. Given the age range of emerging adults, there is tremendous opportunity for clinicians to work cooperatively with colleagues in the education system to support emerging adults with and without CHCs. Overall, clinicians, researchers, educators, and those in social services should continue to be mindful of the complex interrelationships between physical and mental health and chronic disruptive pain and work cooperatively to optimize health outcomes and prevent pain-related disabilities among emerging adults.
易患慢性健康状况(CHCs)相关疼痛后遗症的青年成年人比例有所增加。鉴于在这一重要发育阶段的研究匮乏,本研究调查了青年成年人中慢性健康状况与慢性干扰性疼痛之间的关联,以及精神障碍对这种关联的调节程度。
数据来自2012年加拿大社区健康调查 - 心理健康(CCHS - MH)。这项横断面调查包括5987名年龄在15至30岁之间的参与者,他们自我报告了自己的慢性健康状况(n = 2460,41%),并使用健康效用指数Mark 3(HUI 3)中的项目报告了疼痛对日常功能的影响程度。使用卡方检验对患有慢性健康状况的受访者和健康对照组进行组间比较。从调整了社会人口统计学协变量的有序逻辑回归模型中计算优势比(OR)和95%置信区间(CI)。模型中纳入了慢性健康状况与精神障碍之间的乘积项交互作用,以探讨调节作用。所有分析都进行了加权,以保持研究样本对加拿大人口的代表性。
参与者的平均年龄为23.5(标准误0.1)岁,48%为女性。与健康对照组相比,患有慢性健康状况的参与者中报告有慢性疼痛的比例更高(20.3%对4.5%,p < 0.001)。在患有慢性疼痛的人群中,患有慢性健康状况的受访者报告因慢性干扰性疼痛而被阻止的活动数量更多(χ = 222.28,p < 0.001)。同样,在逻辑回归模型中,患有慢性健康状况的参与者报告慢性干扰性疼痛的几率更高(OR = 4.94,95% CI = 4.08 - 5.99)。发现酒精(β = -0.66;p = 0.025)和药物滥用/依赖障碍(β = -1.24;p = 0.012)调节了慢性健康状况与慢性干扰性疼痛之间的关联。具体而言,对于没有慢性健康状况但有酒精或药物障碍的青年成年人,慢性干扰性疼痛的概率更高;然而,在患有慢性健康状况的参与者中,没有这些障碍的人概率更高。
慢性健康状况与慢性干扰性疼痛之间存在密切关联。调节作用表明,酒精或药物障碍对没有慢性健康状况的青年成年人尤其有害,并导致更高水平的慢性干扰性疼痛;然而,在患有慢性健康状况的人群中,酒精和非法药物可能被用作一种麻醉剂来减轻慢性干扰性疼痛。
本研究的结果对服务的整合与协调具有启示意义,有助于设计旨在管理慢性干扰性疼痛并预防后期与疼痛相关残疾的策略。在卫生系统内,医疗保健提供者应定期与青年成年人就心理健康和物质使用进行对话,积极筛查精神障碍,并持续监测疼痛对日常功能的影响。鉴于青年成年人的年龄范围,临床医生有巨大的机会与教育系统的同事合作,以支持有或没有慢性健康状况的青年成年人。总体而言,临床医生、研究人员、教育工作者和社会服务人员应继续关注身心健康与慢性干扰性疼痛之间的复杂相互关系,并合作优化健康结果,预防青年成年人中与疼痛相关的残疾。