Zhan Jie, Gao Lei, Zhou Fuqing, Kuang Hongmei, Zhao Jing, Wang Siyong, He Laichang, Zeng Xianjun, Gong Honghan
Department of Radiology, the First Affiliated Hospital, Nanchang University, Nanchang City, China.
J Nerv Ment Dis. 2015 Oct;203(10):786-91. doi: 10.1097/NMD.0000000000000368.
Mild traumatic brain injury (mTBI) is characterized by structural disconnection and large-scale neural network dysfunction in the resting state. However, little is known concerning the intrinsic changes in local spontaneous brain activity in patients with mTBI. The aim of the current study was to assess regional synchronization in acute mTBI patients. Fifteen acute mTBI patients and 15 sex-, age-, and education-matched healthy controls (HCs) were studied. We used the regional homogeneity (ReHo) method to map local connectivity across the whole brain and performed a two-sample t-test between the two groups. Compared with HCs, patients with acute mTBI showed significantly decreased ReHo in the left insula, left precentral/postcentral gyrus, and left supramarginal gyrus (p < 0.05, AlphaSim corrected). The ReHo index of the left insula showed a positive correlation with the Mini-Mental State Examination (MMSE) scores across all acute mTBI patients (p < 0.05, uncorrected). The ReHo method may provide an objective biomarker for evaluating the functional abnormity of mTBI in the acute setting.
轻度创伤性脑损伤（mTBI）的特征是静息状态下的结构连接中断和大规模神经网络功能障碍。然而，关于mTBI患者局部自发脑活动的内在变化知之甚少。本研究的目的是评估急性mTBI患者的区域同步性。研究了15例急性mTBI患者和15例性别、年龄和教育程度相匹配的健康对照者（HCs）。我们使用区域同质性（ReHo）方法绘制全脑的局部连接性，并在两组之间进行双样本t检验。与HCs相比，急性mTBI患者在左侧岛叶、左侧中央前/后回和左侧缘上回的ReHo显著降低（p < 0.05，经AlphaSim校正）。在所有急性mTBI患者中，左侧岛叶的ReHo指数与简易精神状态检查表（MMSE）评分呈正相关（p < 0.05，未校正）。ReHo方法可能为评估急性情况下mTBI的功能异常提供一种客观的生物标志物。
