Zhang Jin-Tao, Yao Yuan-Wei, Li Chiang-Shan R, Zang Yu-Feng, Shen Zi-Jiao, Liu Lu, Wang Ling-Jiao, Liu Ben, Fang Xiao-Yi
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, China.
Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, China.
Addict Biol. 2016 May;21(3):743-51. doi: 10.1111/adb.12247. Epub 2015 Apr 20.
The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its association with Internet gaming characteristics in 74 young adults with Internet gaming disorder (IGD) and 41 age- and gender-matched healthy control subjects (HCs). In comparison with HCs, IGD subjects (IGDs) exhibited enhanced rsFC between the anterior insula and a network of regions including anterior cingulate cortex (ACC), putamen, angular gyrus, and precuneous, which are involved in salience, craving, self-monitoring, and attention. IGDs also demonstrated significantly stronger rsFC between the posterior insula and postcentral gyrus, precentral gyrus, supplemental motor area, and superior temporal gyrus (STG), which are involved in interoception, movement control, and auditory processing. Furthermore, IGD severity was positively associated with connectivity between the anterior insula and angular gyrus, and STG, and with connectivity between the posterior insula and STG. Duration of Internet gaming was positively associated with connectivity between the anterior insula and ACC. These findings highlight a key role of the insula in manifestation of the core symptoms of IGD and the importance to examine functional abnormalities of the anterior and posterior insula separately in IGDs.
脑岛已被证明与显著性加工、渴望和内感受有关，所有这些对于药物成瘾和行为成瘾的临床表现都至关重要。在这项功能磁共振成像（fMRI）研究中，我们检查了74名患有网络游戏障碍（IGD）的年轻人和41名年龄及性别匹配的健康对照者（HCs）的脑岛静息态功能连接（rsFC）及其与网络游戏特征的关联。与HCs相比，IGD受试者（IGDs）在前脑岛与包括前扣带回皮质（ACC）、壳核、角回和楔前叶在内的一个区域网络之间表现出增强的rsFC，这些区域参与显著性、渴望、自我监测和注意力。IGDs在后脑岛与中央后回、中央前回、辅助运动区和颞上回（STG）之间也表现出显著更强的rsFC，这些区域参与内感受、运动控制和听觉加工。此外，IGD严重程度与前脑岛和角回以及STG之间的连接性呈正相关，与后脑岛和STG之间的连接性也呈正相关。网络游戏时长与前脑岛和ACC之间的连接性呈正相关。这些发现突出了脑岛在IGD核心症状表现中的关键作用，以及在IGDs中分别检查前脑岛和后脑岛功能异常的重要性。
