Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
J Am Chem Soc. 2013 Mar 27;135(12):4716-8. doi: 10.1021/ja401386z. Epub 2013 Mar 14.
The synthesis of highly functionalized pyrroles has been achieved by reaction of rhodium-stabilized imino-carbenes with furans. The reaction features an initial [3+2] annulation to form bicyclic hemiaminals, followed by ring opening to generate trisubstituted pyrroles.
通过铑稳定的亚氨基卡宾与呋喃的反应，实现了高官能化吡咯的合成。该反应具有初始的[3+2]环加成反应，形成双环半胺，然后开环生成三取代吡咯。
