Zhang Zhi-Pei, Dong Nan, Li Xin, Cheng Jin-Pei
State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China.
Org Biomol Chem. 2015 Oct 21;13(39):9943-7. doi: 10.1039/c5ob01691f.
A highly enantioselective Michael addition reaction of 2-substituted benzofuran-3(2H)-ones to nitroolefins was promoted by a bifunctional squaramide catalyst. As a result, a number of chiral 2,2'-substituted benzofuran-3-one derivatives, bearing adjacent quaternary-tertiary stereocenters, were efficiently synthesized with excellent enantioselectivities.
双功能方酰胺催化剂促进了2-取代苯并呋喃-3(2H)-酮与硝基烯烃的高度对映选择性迈克尔加成反应。结果，高效合成了许多带有相邻季碳-叔碳立体中心的手性2,2'-取代苯并呋喃-3-酮衍生物，对映选择性优异。
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