Alonso Diego A, Baeza Alejandro, Chinchilla Rafael, Gómez Cecilia, Guillena Gabriela, Pastor Isidro M, Ramón Diego J
Department of Organic Chemistry and Institute of Organic Synthesis (ISO), Faculty of Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain.
Molecules. 2017 May 29;22(6):895. doi: 10.3390/molecules22060895.
The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks. Thanks to the rapid development of asymmetric organocatalysis, significant progress has been made during the last years in achieving efficiently this process, concerning chiral organocatalysts, substrates and reaction conditions. This review surveys the advances in asymmetric organocatalytic conjugate addition reactions to α,β-unsaturated nitroalkenes developed between 2013 and early 2017.
碳和杂原子亲核试剂对硝基烯烃的不对称共轭加成是构建高度官能化合成砌块的一种非常有趣的方法。由于不对称有机催化的迅速发展，在过去几年中，在手性有机催化剂、底物和反应条件方面，实现这一过程已取得了重大进展。本文综述了2013年至2017年初开发的α,β-不饱和硝基烯烃不对称有机催化共轭加成反应的研究进展。
