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勃起功能障碍的药物治疗管理

Pharmacotherapeutic management of erectile dysfunction.

作者信息

Hawksworth D J, Burnett A L

机构信息

Department of Urology, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, USA.

Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

出版信息

Clin Pharmacol Ther. 2015 Dec;98(6):602-10. doi: 10.1002/cpt.261. Epub 2015 Oct 30.

Abstract

Erectile dysfunction is a common condition in aging men and significantly affects their quality of life and interpersonal relationships. Its prevalence and incidence are associated with aging, lifestyle factors and cardiovascular comorbidities. Preoccupation with male virility has been present for centuries, and a wide variety of herbs and potions have been used to treat any sexual deficiencies. Recent major advances in understanding of erectile physiology and pathophysiology led to development of currently available systemic and local pharmacotherapies. They are designed to work either centrally or peripherally and to either suppress anti-erectile mechanisms, enhance the pro-erectile ones or influence both. Since all the current formulations have variable safety and efficacy profiles, the search for highly specific, simple, convenient and clinically effective impotence treatments or prophylactics continues.

摘要

勃起功能障碍在老年男性中很常见,会显著影响他们的生活质量和人际关系。其患病率和发病率与衰老、生活方式因素以及心血管合并症有关。对男性阳刚之气的关注已经存在了几个世纪,人们使用了各种各样的草药和药剂来治疗任何性方面的缺陷。最近在勃起生理和病理生理理解方面的重大进展导致了目前可用的全身和局部药物治疗方法的发展。它们旨在通过中枢或外周起作用,要么抑制抗勃起机制,增强促勃起机制,要么同时影响两者。由于目前所有的制剂都有不同的安全性和疗效特征,因此对高度特异性、简单、方便且临床有效的阳痿治疗或预防方法的探索仍在继续。

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