儿童和青少年艾滋病治疗流程的最新情况
An update on the HIV treatment cascade in children and adolescents.
作者信息
Bobat Raziya, Archary Moherndran, Lawler Melissa
机构信息
aDepartment of Paediatrics and Child Health, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal bKing Edward VIII Hospital, Durban, South Africa.
出版信息
Curr Opin HIV AIDS. 2015 Nov;10(6):411-9. doi: 10.1097/COH.0000000000000201.
PURPOSE OF REVIEW
To provide an update on the HIV treatment cascade in children and adolescents. We reviewed the literature on the steps in the cascade, for the period 2014-2015.
RECENT FINDINGS
There remains high attrition of children with regards to early testing and linking those patients who are positive to early treatment. Barriers to screening and testing in children and adolescents are multifactorial. Linkage to pre-antiretroviral therapy care and retention in care are the main steps at which attrition occurs. There are a number of new formulations available for use in adolescents and children which offer more options for antiretroviral therapy treatment. Adherence levels appear to be reasonable in Africa and Asia; however, achieving viral load suppression remains a challenge.
SUMMARY
We have a long way to go to achieve decreased attrition at each step of the cascade and retain patients in care. Recent improvements in each step of the cascade are bringing us closer to achieving treatment success.
综述目的
提供关于儿童和青少年HIV治疗级联反应的最新情况。我们回顾了2014 - 2015年期间有关治疗级联反应各步骤的文献。
最新发现
在早期检测以及将检测呈阳性的患者与早期治疗相联系方面，儿童的流失率仍然很高。儿童和青少年筛查与检测的障碍是多方面的。与抗逆转录病毒治疗护理的联系以及护理中的留存是出现流失的主要环节。有多种新剂型可供青少年和儿童使用，为抗逆转录病毒治疗提供了更多选择。在非洲和亚洲，依从性水平似乎合理；然而，实现病毒载量抑制仍然是一项挑战。
总结
要在治疗级联反应的每个步骤减少流失并使患者持续接受护理，我们还有很长的路要走。治疗级联反应各步骤最近的改进使我们更接近实现治疗成功。
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