ICAP at Columbia, Mailman School of Public Health, College of Physicians & Surgeons, Columbia University, New York, NY.
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD.
J Acquir Immune Defic Syndr. 2018 Aug 15;78 Suppl 1(1):S32-S39. doi: 10.1097/QAI.0000000000001747.
A number of well-described obstacles to the pediatric therapeutic agenda have resulted in substantial delays in the introduction of new medications, formulations, strategies, and approaches to treat infants, children, and adolescents living with HIV.
Global landscape.
The authors will provide a summary of current and emerging initiatives to accelerate the pediatric therapeutic agenda including illustrative case studies of innovations and scientific discovery in diagnosis and treatment of very young children with HIV infection.
The challenges posed by rapid physiologic and developmental changes that characterize the trajectory of childhood as well as the complex regulatory and fiscal milieu of HIV therapeutics have hampered pediatric HIV therapeutic research. Recent efforts to accelerate this agenda include prioritizing agents and formulations, defining dosing by weight bands, applying innovative study designs, synergizing work across research networks to achieve common goals, and the establishment of a global prioritized research agenda. A case study of initiatives to diagnose and effectively treat newborns and infants will illustrate the critical role of basic science research and novel approaches to study design and implementation that are informing global efforts to end AIDS.
A pediatric therapeutic agenda informed by basic science and achieved through innovation and global cooperation is essential to achieve an AIDS-free generation.
许多描述详尽的儿科治疗障碍导致新药物、配方、策略和方法的引入出现了实质性的延迟，这些障碍旨在治疗感染艾滋病毒的婴儿、儿童和青少年。
全球范围。
作者将提供一份总结，内容是为加速儿科治疗议程而采取的当前和新兴举措，包括诊断和治疗 HIV 感染的非常年幼的儿童方面的创新和科学发现的说明性案例研究。
儿童时期的轨迹特征是快速的生理和发育变化，以及 HIV 治疗的复杂监管和财政环境，这些都给儿科 HIV 治疗研究带来了挑战。最近为加速这一议程所做的努力包括优先考虑药物和配方、按体重带定义剂量、应用创新的研究设计、在研究网络之间协同工作以实现共同目标，以及制定全球优先研究议程。诊断和有效治疗新生儿和婴儿的举措案例研究将说明基础科学研究以及创新的研究设计和实施方法的关键作用，这些方法正在为全球消除艾滋病的努力提供信息。
以基础科学为指导，通过创新和全球合作实现的儿科治疗议程，对于实现无艾滋病一代至关重要。
