这场革命不会被固化：一种新方法席卷结构生物学领域。 - Suppr

Suppr

超能文献

The revolution will not be crystallized: a new method sweeps through structural biology.

作者信息

Callaway Ewen

出版信息

Nature. 2015 Sep 10;525(7568):172-4. doi: 10.1038/525172a.

DOI:10.1038/525172a

PMID:26354465

Abstract

摘要

相似文献

The revolution will not be crystallized: a new method sweeps through structural biology.

Nature. 2015 Sep 10;525(7568):172-4. doi: 10.1038/525172a.

Structural Molecular Biology-A Personal Reflection on the Occasion of John Kendrew's 100th Birthday.

J Mol Biol. 2017 Aug 18;429(17):2603-2610. doi: 10.1016/j.jmb.2017.05.007. Epub 2017 May 10.

Biophysical Techniques in Structural Biology.

Annu Rev Biochem. 2019 Jun 20;88:25-33. doi: 10.1146/annurev-biochem-013118-111947. Epub 2019 Apr 15.

Marking the Milestones in Structural Biology.

J Mol Biol. 2017 Aug 18;429(17):2591-2593. doi: 10.1016/j.jmb.2017.07.019. Epub 2017 Jul 29.

Electron cryo-microscopy: the frozen frontier of structural biology.

Yale J Biol Med. 2001 Sep-Oct;74(5):355-60.

Editorial overview: Biophysical methods: behind the scenes of the cryo-EM revolution.

Curr Opin Struct Biol. 2017 Oct;46:ix-xi. doi: 10.1016/j.sbi.2017.10.018.

The resolution revolution in X-ray diffraction, Cryo-EM and other Technologies.

Prog Biophys Mol Biol. 2021 Mar;160:2-4. doi: 10.1016/j.pbiomolbio.2021.01.003. Epub 2021 Jan 21.

Revolutionary cryo-EM is taking over structural biology.

Nature. 2020 Feb;578(7794):201. doi: 10.1038/d41586-020-00341-9.

Soft-landing methods aim to simplify structural biology.

Nature. 2023 Oct;622(7983):658-660. doi: 10.1038/d41586-023-03236-7.

On the complementarity of methods in structural biology.

Acta Crystallogr D Biol Crystallogr. 2006 Aug;62(Pt 8):941-5. doi: 10.1107/S0907444906008900. Epub 2006 Jul 18.

引用本文的文献

A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa.

Nat Commun. 2025 Aug 29;16(1):8082. doi: 10.1038/s41467-025-63379-1.

Structural Biology in the AlphaFold Era: How Far Is Artificial Intelligence from Deciphering the Protein Folding Code?

Biomolecules. 2025 May 6;15(5):674. doi: 10.3390/biom15050674.

A comprehensive review on structural insights through molecular visualization: tools, applications, and limitations.

J Mol Model. 2025 May 27;31(6):173. doi: 10.1007/s00894-025-06402-y.

Nanodiscs remain indispensable for Cryo-EM studies of membrane proteins.

Curr Opin Struct Biol. 2025 Jun;92:103042. doi: 10.1016/j.sbi.2025.103042. Epub 2025 Apr 8.

Macromolecular crystallography from an industrial perspective - the impact of synchrotron radiation on structure-based drug discovery.

J Synchrotron Radiat. 2025 Mar 1;32(Pt 2):294-303. doi: 10.1107/S1600577524012281. Epub 2025 Feb 6.

Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders.

RSC Med Chem. 2024 Nov 20. doi: 10.1039/d4md00576g.

Computational prediction of multiple antigen epitopes.

Bioinformatics. 2024 Oct 1;40(10). doi: 10.1093/bioinformatics/btae556.

Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.

Biology (Basel). 2024 Apr 26;13(5):298. doi: 10.3390/biology13050298.

VitroJet: new features and case studies.

Acta Crystallogr D Struct Biol. 2024 Apr 1;80(Pt 4):232-246. doi: 10.1107/S2059798324001852. Epub 2024 Mar 15.

Multiparameter screen optimizes immunoprecipitation.

Biotechniques. 2024 Apr;76(4):145-152. doi: 10.2144/btn-2023-0051. Epub 2024 Feb 29.

本文引用的文献

An atomic structure of human γ-secretase.

Nature. 2015 Sep 10;525(7568):212-217. doi: 10.1038/nature14892. Epub 2015 Aug 17.

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase.

Nature. 2015 May 14;521(7551):241-5. doi: 10.1038/nature14365.

2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.

Science. 2015 Jun 5;348(6239):1147-51. doi: 10.1126/science.aab1576. Epub 2015 May 7.

Structure of the human 80S ribosome.

Nature. 2015 Apr 30;520(7549):640-5. doi: 10.1038/nature14427. Epub 2015 Apr 22.

Ribosome. The structure of the human mitochondrial ribosome.

Science. 2015 Apr 3;348(6230):95-98. doi: 10.1126/science.aaa1193. Epub 2015 Apr 2.

Reply to Subramaniam, van Heel, and Henderson: Validity of the cryo-electron microscopy structures of the HIV-1 envelope glycoprotein complex.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4178-82. doi: 10.1073/pnas.1316666110.

Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

Nature. 2013 Dec 5;504(7478):107-12. doi: 10.1038/nature12822.

Avoiding the pitfalls of single particle cryo-electron microscopy: Einstein from noise.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18037-41. doi: 10.1073/pnas.1314449110. Epub 2013 Oct 8.

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43. doi: 10.1073/pnas.1307382110. Epub 2013 Jun 11.

Human TFIID binds to core promoter DNA in a reorganized structural state.

Cell. 2013 Jan 17;152(1-2):120-31. doi: 10.1016/j.cell.2012.12.005.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

The revolution will not be crystallized: a new method sweeps through structural biology.

Nature. 2015 Sep 10;525(7568):172-4. doi: 10.1038/525172a.

Structural Molecular Biology-A Personal Reflection on the Occasion of John Kendrew's 100th Birthday.

J Mol Biol. 2017 Aug 18;429(17):2603-2610. doi: 10.1016/j.jmb.2017.05.007. Epub 2017 May 10.

Biophysical Techniques in Structural Biology.

Annu Rev Biochem. 2019 Jun 20;88:25-33. doi: 10.1146/annurev-biochem-013118-111947. Epub 2019 Apr 15.

Marking the Milestones in Structural Biology.

J Mol Biol. 2017 Aug 18;429(17):2591-2593. doi: 10.1016/j.jmb.2017.07.019. Epub 2017 Jul 29.

Electron cryo-microscopy: the frozen frontier of structural biology.

Yale J Biol Med. 2001 Sep-Oct;74(5):355-60.

Editorial overview: Biophysical methods: behind the scenes of the cryo-EM revolution.

Curr Opin Struct Biol. 2017 Oct;46:ix-xi. doi: 10.1016/j.sbi.2017.10.018.

The resolution revolution in X-ray diffraction, Cryo-EM and other Technologies.

Prog Biophys Mol Biol. 2021 Mar;160:2-4. doi: 10.1016/j.pbiomolbio.2021.01.003. Epub 2021 Jan 21.

Revolutionary cryo-EM is taking over structural biology.

Nature. 2020 Feb;578(7794):201. doi: 10.1038/d41586-020-00341-9.

Soft-landing methods aim to simplify structural biology.

Nature. 2023 Oct;622(7983):658-660. doi: 10.1038/d41586-023-03236-7.

On the complementarity of methods in structural biology.

Acta Crystallogr D Biol Crystallogr. 2006 Aug;62(Pt 8):941-5. doi: 10.1107/S0907444906008900. Epub 2006 Jul 18.

引用本文的文献

A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa.

Nat Commun. 2025 Aug 29;16(1):8082. doi: 10.1038/s41467-025-63379-1.

Structural Biology in the AlphaFold Era: How Far Is Artificial Intelligence from Deciphering the Protein Folding Code?

Biomolecules. 2025 May 6;15(5):674. doi: 10.3390/biom15050674.

A comprehensive review on structural insights through molecular visualization: tools, applications, and limitations.

J Mol Model. 2025 May 27;31(6):173. doi: 10.1007/s00894-025-06402-y.

Nanodiscs remain indispensable for Cryo-EM studies of membrane proteins.

Curr Opin Struct Biol. 2025 Jun;92:103042. doi: 10.1016/j.sbi.2025.103042. Epub 2025 Apr 8.

Macromolecular crystallography from an industrial perspective - the impact of synchrotron radiation on structure-based drug discovery.

J Synchrotron Radiat. 2025 Mar 1;32(Pt 2):294-303. doi: 10.1107/S1600577524012281. Epub 2025 Feb 6.

Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders.

RSC Med Chem. 2024 Nov 20. doi: 10.1039/d4md00576g.

Computational prediction of multiple antigen epitopes.

Bioinformatics. 2024 Oct 1;40(10). doi: 10.1093/bioinformatics/btae556.

Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.

Biology (Basel). 2024 Apr 26;13(5):298. doi: 10.3390/biology13050298.

VitroJet: new features and case studies.

Acta Crystallogr D Struct Biol. 2024 Apr 1;80(Pt 4):232-246. doi: 10.1107/S2059798324001852. Epub 2024 Mar 15.

Multiparameter screen optimizes immunoprecipitation.

Biotechniques. 2024 Apr;76(4):145-152. doi: 10.2144/btn-2023-0051. Epub 2024 Feb 29.

本文引用的文献

An atomic structure of human γ-secretase.

Nature. 2015 Sep 10;525(7568):212-217. doi: 10.1038/nature14892. Epub 2015 Aug 17.

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase.

Nature. 2015 May 14;521(7551):241-5. doi: 10.1038/nature14365.

2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.

Science. 2015 Jun 5;348(6239):1147-51. doi: 10.1126/science.aab1576. Epub 2015 May 7.

Structure of the human 80S ribosome.

Nature. 2015 Apr 30;520(7549):640-5. doi: 10.1038/nature14427. Epub 2015 Apr 22.

Ribosome. The structure of the human mitochondrial ribosome.

Science. 2015 Apr 3;348(6230):95-98. doi: 10.1126/science.aaa1193. Epub 2015 Apr 2.

Reply to Subramaniam, van Heel, and Henderson: Validity of the cryo-electron microscopy structures of the HIV-1 envelope glycoprotein complex.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4178-82. doi: 10.1073/pnas.1316666110.

Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

Nature. 2013 Dec 5;504(7478):107-12. doi: 10.1038/nature12822.

Avoiding the pitfalls of single particle cryo-electron microscopy: Einstein from noise.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18037-41. doi: 10.1073/pnas.1314449110. Epub 2013 Oct 8.

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43. doi: 10.1073/pnas.1307382110. Epub 2013 Jun 11.

Human TFIID binds to core promoter DNA in a reorganized structural state.

Cell. 2013 Jan 17;152(1-2):120-31. doi: 10.1016/j.cell.2012.12.005.