上皮细胞中的免疫稳态：炎症小体信号的证据和作用综述。
Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed.
机构信息
Department of Respiratory Medicine, Nutrim School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, Netherlands ; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Department of Respiratory Medicine, Nutrim School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, Netherlands.
出版信息
J Immunol Res. 2015;2015:828264. doi: 10.1155/2015/828264. Epub 2015 Aug 19.
The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis.
上皮组织不仅通过提供屏障，还通过表达许多免疫调节膜受体、细胞内危险传感器及其下游效应器，来调节有害异源物质以及微生物环境和免疫系统之间的相互作用。其中有许多炎症小体传感器亚型，最初在髓样细胞中被描述，并被描述为在微生物和环境触发因素的作用下组装成多蛋白复合物时被激活。这篇综述汇集了大量文献，支持炎症小体在人体各种上皮屏障中作为维持免疫信号和内稳态的重要因素发挥关键作用。
Zotero 插件