The Skin Innate Immunity and Inflammatory Disease Lab, Skin Research Centre, Department of Hull York Medical School, University of York, UK.
York Biomedical Research Institute, University of York, UK.
FEBS Lett. 2024 Jun;598(11):1335-1353. doi: 10.1002/1873-3468.14848. Epub 2024 Mar 14.
Our epithelium represents a battle ground against a variety of insults including pathogens and danger signals. It encodes multiple sensors that detect and respond to such insults, playing an essential role in maintaining and defending tissue homeostasis. One key set of defense mechanisms is our inflammasomes which drive innate immune responses including, sensing and responding to pathogen attack, through the secretion of pro-inflammatory cytokines and cell death. Identification of physiologically relevant triggers for inflammasomes has greatly influenced our ability to decipher the mechanisms behind inflammasome activation. Furthermore, identification of patient mutations within inflammasome components implicates their involvement in a range of epithelial diseases. This review will focus on exploring the roles of inflammasomes in epithelial immunity and cover: the diversity and differential expression of inflammasome sensors amongst our epithelial barriers, their ability to sense local infection and damage and the contribution of the inflammasomes to epithelial homeostasis and disease.
我们的上皮组织代表了与多种刺激物（包括病原体和危险信号）作斗争的战场。它编码了多种传感器，可以检测和响应这些刺激物，在上皮组织的维持和防御中发挥着重要作用。一组关键的防御机制是我们的炎症小体，它通过促炎细胞因子的分泌和细胞死亡来驱动先天免疫反应，包括感知和应对病原体的攻击。炎症小体激活机制背后的机制的破译能力大大提高了我们对生理相关触发物的识别能力。此外，炎症小体成分中的患者突变的鉴定表明它们参与了一系列上皮疾病。本综述将重点探讨炎症小体在上皮免疫中的作用，涵盖：我们上皮屏障中炎症小体传感器的多样性和差异表达，它们感知局部感染和损伤的能力，以及炎症小体对上皮组织稳态和疾病的贡献。
