含螺碳环天然产物的全合成。

Total syntheses of natural products containing spirocarbocycles.

作者信息

Smith Laura K, Baxendale Ian R

机构信息

Department of Chemistry, Durham University, Stockton Road, Durham, DH1 3LE, UK.

出版信息

Org Biomol Chem. 2015 Oct 21;13(39):9907-33. doi: 10.1039/c5ob01524c.

DOI:10.1039/c5ob01524c

PMID:26356301

Abstract

The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.

摘要

来自各种来源的天然产物结构中含有螺环，即两个共享一个公共原子的环。螺环结构在候选药物中的应用越来越多，并且作为不对称合成中使用的几类有前景的手性配体的结构组成部分。含有全碳螺环的产物的全合成具有几种常见的环化方法，我们将在本综述中对其进行研究。