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[皮质素。神经保护活性的分子机制与靶点]

[Cortexin. Molecular mechanisms and targets of neuroprotective activity].

作者信息

Gomazkov O A

机构信息

Orekhovich Institute of Biomedical Chemistry, Moscow.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(8):99-104. doi: 10.17116/jnevro20151158199-104.

Abstract

Neurotrophic drug cortexin, a lyophilized extraction of animal cortex, comprises neuropeptides, amino acids and trace elements. The nucleoprotein complexes of the cerebral cortex can also retain elements of chromatin with DNA fragments. All of these components of cortexin have a specific range of "targets" for the specific correction of the molecular and cellular processes at various stages of the pathological process. A modern concept of neurosignaling considers the associated processes - from the synaptic level to the epigenetic patterns of neuron nucleus, in which an important place belongs to corrective peptide molecules. Peptide components of cortexin derived from the animal brain, which interact with cellular and molecular "targets", provide a new view on mechanisms of neuroprotection.

摘要

神经营养药物皮质素是一种动物皮质的冻干提取物,包含神经肽、氨基酸和微量元素。大脑皮质的核蛋白复合物也能保留带有DNA片段的染色质成分。皮质素的所有这些成分在病理过程的各个阶段对分子和细胞过程进行特定校正时都有特定范围的“靶点”。神经信号传导的现代概念考虑了从突触水平到神经元核表观遗传模式的相关过程,其中校正肽分子占有重要地位。源自动物大脑的皮质素肽成分与细胞和分子“靶点”相互作用,为神经保护机制提供了新的视角。

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