Khoreva M A
Altai State Medical University, Russian Ministry of Health, Barnaul, Russia.
Neurosci Behav Physiol. 2022;52(5):619-624. doi: 10.1007/s11055-022-01286-4. Epub 2022 Sep 13.
The second year of the COVID-19 pandemic has demonstrated the need for detection and assessment of the long-term consequences SARS-CoV-2 infection, including adequate cognitive functioning. This review addresses our current understanding of the direct and indirect mechanisms of nervous system infection in COVID-19, paying special attention to cause-effect relationships between SARS-CoV-2 infection and long-term neuropsychological disorders. Understanding the pathogenesis of neurological impairments in COVID-19 is important for studies of the long-term sequelae of the disease and for identifying preventive and therapeutic possibilities in relation to brain damage. Further studies of nervous system lesions in COVID-19 are clearly needed to expand existing knowledge. Early initiation of therapeutic measures for emerging disorders will probably have decisive importance for improving quality of life for many COVID-19 survivors.
新冠疫情的第二年表明,有必要对新冠病毒感染的长期后果进行检测和评估,包括认知功能是否正常。本综述阐述了我们目前对新冠病毒感染神经系统的直接和间接机制的理解,特别关注新冠病毒感染与长期神经心理障碍之间的因果关系。了解新冠病毒感染导致神经损伤的发病机制,对于研究该疾病的长期后遗症以及确定与脑损伤相关的预防和治疗方法具有重要意义。显然需要进一步研究新冠病毒感染导致的神经系统损伤,以拓展现有知识。对于许多新冠病毒感染者而言,尽早针对新出现的病症采取治疗措施,可能对改善他们的生活质量具有决定性意义。