Aksoy Şefika Nur, Savaş Esen, Sucu Murat, Kisacik Bünyamin, Kul Seval, Zengin Orhan
Department of Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
Department of Internal Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
J Int Med Res. 2015 Dec;43(6):765-73. doi: 10.1177/0300060515591063. Epub 2015 Sep 10.
To examine associations between red blood cell distribution width (RDW) and organ involvement and disease activity in patients with Behçet's disease.
Haematological and inflammatory parameters including RDW, high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR) were examined in patients with Behçet's disease and in healthy controls. Patients were divided into those with active or inactive disease.
Data from 236 patients with Behçet's disease (77 with active and 159 with inactive disease) and 72 controls were analysed. RDW, ESR and hsCRP were significantly higher in patients with Behçet's disease than in controls, and in those with active disease compared with inactive disease or controls. In addition, ESR and hsCRP were significantly higher in those with inactive disease than controls. No correlations were found between hsCRP, ESR and RDW. No differences were observed in RDW, ESR or hsCRP between patients with or without ocular or vascular involvement. Multivariate logistic regression analysis revealed that RDW was significantly higher in active disease compared with inactive disease.
RDW was increased in active disease compared with inactive disease. No relationships were found between organ involvement and RDW. RDW may be a cost-effective, novel potential parameter to evaluate disease activity in Behçet's disease.
研究白塞病患者红细胞分布宽度（RDW）与器官受累及疾病活动度之间的关联。
对白塞病患者和健康对照者进行血液学和炎症参数检测，包括RDW、高敏C反应蛋白（hsCRP）和红细胞沉降率（ESR）。将患者分为疾病活动期和非活动期。
分析了236例白塞病患者（77例活动期和159例非活动期）及72例对照者的数据。白塞病患者的RDW、ESR和hsCRP显著高于对照组，且活动期患者高于非活动期患者或对照组。此外，非活动期患者的ESR和hsCRP也显著高于对照组。hsCRP、ESR与RDW之间未发现相关性。有或无眼部或血管受累的患者在RDW、ESR或hsCRP方面未观察到差异。多因素逻辑回归分析显示，活动期疾病患者的RDW显著高于非活动期疾病患者。
与非活动期疾病相比，活动期疾病患者的RDW升高。未发现器官受累与RDW之间存在关联。RDW可能是评估白塞病疾病活动度的一个具有成本效益的新型潜在参数。
