Hong Jing, Zhu Bin, Cai Xintian, Liu Shanshan, Liu Shasha, Zhu Qing, Aierken Xiayire, Aihemaiti Ayiguzaili, Wu Ting, Li Nanfang
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, NHC Key Laboratory of Hypertension Clinical Research, Hypertension Institute of Xinjiang, Tianshan, Urumqi, Xinjiang 830001, P.R. China.
Exp Ther Med. 2021 Jul;22(1):691. doi: 10.3892/etm.2021.10123. Epub 2021 May 2.
The present study aimed to investigate whether red blood cell distribution width (RDW) could serve as a marker for estimating disease activity in patients with systemic vasculitis (SV). A total of 287 patients with SV and 64 age- and sex-matched healthy controls (HCs) were included in the present study. Biochemical indicators and hematologic parameters were evaluated in patients with SV and the HCs. Disease activity was assessed on the basis of the Birmingham Vasculitis Activity Score (BVAS). RDW was significantly elevated in patients with SV compared with HCs (P<0.05). A similar result was obtained for the comparison of patients with various disease states, active vs. inactive (P<0.05). RDW was significantly increased in patients with kidney injury compared with patients without kidney injury (P<0.05). The correlation analysis indicated that there were positive correlations between RDW and BVAS, erythrocyte sedimentation rate, high-sensitivity C-reactive protein, white blood cells and serum creatinine (Scr; all P<0.05). In addition, there was a significant negative correlation between RDW and hemoglobin levels (P<0.05). Multivariate logistic regression analysis indicated that RDW was independently correlated with patients with active SV. The combined diagnosis of RDW and Scr indicated that the sensitivity and specificity were 68.6 and 88.9%, respectively, in terms of assessing disease activity in patients with SV. Therefore, the present study suggested that RDW may serve as a useful index for estimating disease activity and kidney injury in patients with SV. Moreover, the combination of RDW and Scr may be more effective than RDW alone when assessing the risk of disease activity in patients with SV.
本研究旨在调查红细胞分布宽度（RDW）是否可作为评估系统性血管炎（SV）患者疾病活动度的标志物。本研究共纳入了287例SV患者和64例年龄及性别匹配的健康对照者（HCs）。对SV患者和HCs进行了生化指标和血液学参数评估。根据伯明翰血管炎活动评分（BVAS）评估疾病活动度。与HCs相比，SV患者的RDW显著升高（P<0.05）。在比较不同疾病状态（活动期与非活动期）的患者时也得到了类似结果（P<0.05）。与无肾损伤的患者相比，有肾损伤的患者RDW显著升高（P<0.05）。相关性分析表明，RDW与BVAS、红细胞沉降率、高敏C反应蛋白、白细胞和血清肌酐（Scr；均P<0.05）之间存在正相关。此外，RDW与血红蛋白水平之间存在显著负相关（P<0.05）。多因素逻辑回归分析表明，RDW与活动期SV患者独立相关。RDW和Scr的联合诊断表明，在评估SV患者的疾病活动度方面，敏感性和特异性分别为68.6%和88.9%。因此，本研究表明，RDW可能是评估SV患者疾病活动度和肾损伤的有用指标。此外，在评估SV患者疾病活动风险时，RDW和Scr联合使用可能比单独使用RDW更有效。
