Wang J, Zhang H, Wu C, Han J, Guo Z, Jia C, Yang L, Hao Y, Xu K, Liu X, Si J
Department of Ultrasound, The First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Department of Radiology, The First Hospital of Shanxi Medical University, No. 85 Jiefangnan Road, Nancheng District, Taiyuan 030001, China.
West Indian Med J. 2015 Mar;64(2):92-8. doi: 10.7727/wimj.2014.054. Epub 2015 Feb 3.
The aim of this study is to evaluate the correlation of the left ventricular diastolic function and the left ventricular geometry in patients with obstructive sleep apnoea syndrome (OSAS) by echocardiography.
The 181 patients diagnosed with OSAS were divided into the normal geometry group (NG), the concentric remodelling group (CR), the eccentric hypertrophy group (EH) and the concentric hypertrophy group (CH). Pearson correlation analysis and multiple linear regression analysis were performed toward the correlation of the left ventricular diastolic function and the left ventricular geometry.
The E peak in the EH and CH group was significantly reduced, with significant difference; the E/A, Em, Am and Em/Am was reduced in the order of the CR, EH and CH groups, while E/Em was increased, and the difference was significant. Pearson correlation analysis revealed that the Em/Am showed significant negative correlations with the left ventricular mass index (LVMI) [r = -0.419] and relative wall thickness (RWT) [r = -0.289], while the E/Em was significantly positively correlated with the LVMI (r = 0.638) and RWT [r = 0.328] (p < 0.001). Multiple linear regression analysis revealed that LVMI and RWT had influence on the Em/Am and E/Em (r2 = 0.402, r2 = 0.107, p < 0.001). The left ventricular diastolic dysfunction was the worst in the CH group.
There was correlation between the left ventricular diastolic dysfunction and the changes in cardiac geometry.
本研究旨在通过超声心动图评估阻塞性睡眠呼吸暂停综合征（OSAS）患者左心室舒张功能与左心室几何形态的相关性。
将181例确诊为OSAS的患者分为正常几何形态组（NG）、向心性重构组（CR）、离心性肥厚组（EH）和向心性肥厚组（CH）。对左心室舒张功能与左心室几何形态的相关性进行Pearson相关分析和多元线性回归分析。
EH组和CH组的E峰显著降低，差异有统计学意义；E/A、Em、Am和Em/Am按CR组、EH组和CH组顺序降低，而E/Em升高，差异有统计学意义。Pearson相关分析显示，Em/Am与左心室质量指数（LVMI）[r = -0.419]和相对室壁厚度（RWT）[r = -0.289]呈显著负相关，而E/Em与LVMI（r = 0.638）和RWT[r = 0.328]呈显著正相关（p < 0.001）。多元线性回归分析显示，LVMI和RWT对Em/Am和E/Em有影响（r2 = 0.402，r2 = 0.107，p < 0.001）。CH组左心室舒张功能障碍最严重。
左心室舒张功能障碍与心脏几何形态变化之间存在相关性。
