Huang L, Zhu S J, Xin Q
Zhonghua Nei Ke Za Zhi. 1989 Dec;28(12):717-9, 767.
The characteristics of ischemic episodes in exercise test and daily activities were observed in a silent myocardial ischemia (SMI) group and an anginal group (23 patients each). 15 patients in the SMI group were treated with nifedipine. In exercise test, the time of onset of ischemia was earlier and the ischemic threshold was lower in SMI group. During daily activities, the frequency of SMI was high. The heart rate just before onset of SMI was lower than the mean heart rate in 24-hour Holter monitoring. The highest frequency of SMI was found between 5 AM and 12 noon. Postinfarction patients had a higher frequency and a longer duration of SMI than noninfarction patients. The frequency and duration of SMI decreased in the 15 patients treated with nifedipine in SMI group. It is concluded that silent ischemic episodes were frequent and occurred easily. They might be associated with poor prognosis in CAD patients. Nifedipine was effective in reducing the frequency and duration of SMI in our patients.
在一个无症状心肌缺血（SMI）组和一个心绞痛组（每组23例患者）中观察了运动试验和日常活动中缺血发作的特征。SMI组中的15例患者接受了硝苯地平治疗。在运动试验中，SMI组缺血发作时间更早且缺血阈值更低。在日常活动期间，SMI的发作频率较高。SMI发作前的心率低于24小时动态心电图监测中的平均心率。SMI的最高发作频率出现在上午5点至中午12点之间。心肌梗死后患者的SMI发作频率更高、持续时间更长，比未发生心肌梗死的患者情况更严重。SMI组中接受硝苯地平治疗的15例患者的SMI发作频率和持续时间有所下降。得出的结论是，无症状缺血发作频繁且易于发生。它们可能与CAD患者的不良预后相关。硝苯地平在降低我们患者的SMI发作频率和持续时间方面是有效的。
