el-Zoghby S A, el-Zainy M A
Egypt Dent J. 1989 Jan;35(1):31-45.
The effects of different doses of lidocaine with or without epinephrine on the rat's salivary glands were studied in this report. 60 adult male albino rats were divided into 4 experimental groups and one control group' 1 st group, the salivary glands were injected with 0.1 ml of 2% lidocaine Hcl. 2 nd group, the salivary glands were injected with 0.5 ml of 2% lidocaine Hcl. 3 rd group, the salivary glands were injected with 0.1 ml of lidocaine Hcl + 1/200,000 epinephrine, while the 4 th group, the glands were injected with 0.1 ml of lidocaine Hcl + 1/80.000 epinephrine. The control group was injected with 0.1 ml of physiologic asline. Each group of animals was subdivided into 3 subgroups A, B, and C according to the sacrifice periods which were 24, 48 and 72 hours respectively. After sacrification the submandibular salivary glands were removed and prepared for histological and histochemical studies. Our results revealed that, lidocaine in relevant doses with or without epinephrine produced reversible damage to the terminal portions of salivary glands. Large doses of lidocaine produced massive damage and delayed healing. Epinephrine concentration of 1/200.000 is recomended by the authors as higher concentration produced sever and extensive damage.
本报告研究了不同剂量的利多卡因加或不加肾上腺素对大鼠唾液腺的影响。60只成年雄性白化大鼠被分为4个实验组和1个对照组。第1组，唾液腺注射0.1毫升2%盐酸利多卡因；第2组，唾液腺注射0.5毫升2%盐酸利多卡因；第3组，唾液腺注射0.1毫升利多卡因盐酸盐+1/200,000肾上腺素，而第4组，唾液腺注射0.1毫升利多卡因盐酸盐+1/80,000肾上腺素。对照组注射0.1毫升生理盐溶液。每组动物根据处死时间分别为24、48和72小时再细分为3个亚组A、B和C。处死后，取出下颌下唾液腺，准备进行组织学和组织化学研究。我们的结果显示，相关剂量的利多卡因加或不加肾上腺素对唾液腺终末部分产生可逆性损伤。大剂量利多卡因造成大量损伤且愈合延迟。作者推荐1/200,000的肾上腺素浓度，因为更高浓度会造成严重且广泛的损伤。
