Lin C K, Gau J P, Ho C H, Wang S Y
Taiwan Yi Xue Hui Za Zhi. 1989 Nov-Dec;88(11-12):1123-7.
Ninety patients with a strict diagnosis of aplastic anemia were observed during a 4-year period. The incidence of aplastic anemia is estimated to be much higher here than in western countries. A disproportionately large number of young males were noted among our patients. Two cases were congenital. One case presented a past history of paroxysmal nocturnal hemoglobinuria. The etiology of 8 cases (8.9%) could be attributed to drugs and/or chemicals. In the remaining 79 cases (87.8%), the causes of the disease were unknown. The carrier rate of the hepatitis B surface antigen in the patients with aplastic anemia was similar to that of the general population, and chronic hepatitis B infection was not considered a major etiological factor. Coexistence of abnormal liver functions at the initial presentation was noted in 21.9% of the patients. Exposure to unknown drugs by self-medication was possibly one of the major causes of the high incidence of aplastic anemia and the associated abnormal liver functions in our patients.
在4年期间观察了90例确诊为再生障碍性贫血的患者。据估计，这里再生障碍性贫血的发病率比西方国家高得多。我们的患者中年轻男性的比例过高。有2例为先天性。1例有阵发性夜间血红蛋白尿病史。8例（8.9%）的病因可归因于药物和/或化学物质。其余79例（87.8%）病因不明。再生障碍性贫血患者的乙肝表面抗原携带率与普通人群相似，慢性乙肝感染不被认为是主要病因。21.9%的患者在初次就诊时存在肝功能异常。自行服用不明药物可能是我们的患者中再生障碍性贫血高发病率及相关肝功能异常的主要原因之一。
