交通事故后由伞枝犁头霉引起的皮肤毛霉病的早期诊断
Early Diagnosis of Cutaneous Mucormycosis Due to Lichtheimia corymbifera After a Traffic Accident.
作者信息
Tyll Tomas, Lyskova Pavlina, Hubka Vit, Muller Martin, Zelenka Lubomir, Curdova Martina, Tuckova Inna, Kolarik Miroslav, Hamal Petr
机构信息
Department of Anesthesiology, Resuscitation and Intensive Care Medicine, First Faculty of Medicine, Charles University in Prague and the Military University Hospital Prague, U Vojenske Nemocnice 1200, 169 02, Prague 6, Czech Republic.
Laboratory of Medical Mycology, Department of Parasitology, Mycology and Mycobacteriology Prague, Public Health Institute in Usti nad Labem, Sokolovska 60, 186 00, Prague 8, Czech Republic.
出版信息
Mycopathologia. 2016 Feb;181(1-2):119-24. doi: 10.1007/s11046-015-9943-9. Epub 2015 Sep 12.
A case report of cutaneous mucormycosis and obstacles to early diagnosis is presented. A 38-year-old male was involved in a car accident that led to amputation of both lower limbs. Subsequently, he developed fungal wound infection of the left lower limb stump. The infection was detected very early, although the diagnosis was difficult because only a small area was affected and histopathological examination was initially negative. The infection was proven by microscopy, culture and histopathology. The isolate was identified by sequencing of the rDNA ITS region gene (internal transcribed spacer region of ribosomal DNA) as Lichtheimia corymbifera. Liposomal amphotericin B and surgery were successful in management of the disease.
本文报告一例皮肤毛霉病病例及早期诊断面临的障碍。一名38岁男性遭遇车祸，导致双下肢截肢。随后，他的左下肢残端出现真菌伤口感染。尽管感染发现得很早，但诊断困难，因为仅小面积受累且组织病理学检查最初为阴性。通过显微镜检查、培养和组织病理学证实了感染。通过对rDNA ITS区域基因（核糖体DNA的内部转录间隔区）进行测序，将分离株鉴定为伞枝犁头霉。脂质体两性霉素B和手术成功治愈了该疾病。
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