对一名可能患有脑毛霉病且接受静脉注射脂质体两性霉素B治疗的患者脑脊液中毛霉目DNA载量的评估。
Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B.
作者信息
Shigemura Tomonari, Nakazawa Yozo, Matsuda Kazuyuki, Motobayashi Mitsuo, Saito Shoji, Koike Kenichi
机构信息
Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
出版信息
Int J Infect Dis. 2014 Dec;29:200-2. doi: 10.1016/j.ijid.2014.10.019. Epub 2014 Nov 6.
We report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0×10(4) copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichtheimia DNA load fell below the detection limit, and at the same time the patient's headache and imaging findings improved. The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis.
我们报告了一例19岁男性在化疗后可能患有脑毛霉菌病的病例。尽管脑脊液（CSF）培养无生长，但我们在脑脊液中检测到 Lichtheimia DNA载量为2.0×10(4) 拷贝/毫升。经静脉注射脂质体两性霉素B治疗后，Lichtheimia DNA载量降至检测限以下，同时患者的头痛及影像学表现有所改善。脑脊液中毛霉目DNA的定量分析可能有助于评估脑毛霉菌病。
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