来自缅甸八角茎皮的异戊烯基化苯丙素类化合物。
Prenylated phenylpropanoid compounds from the stem bark of Illicium burmanicum.
作者信息
Huang Doudou, Zhu Haiying, Chen Yanhong, Chen Wansheng, Xue Dan, Sun Lianna
机构信息
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
Department of Cell Biology, Second Military Medical University, Shanghai 200433, People's Republic of China.
出版信息
Fitoterapia. 2015 Dec;107:22-28. doi: 10.1016/j.fitote.2015.09.009. Epub 2015 Sep 11.
Ten new prenylated phenylpropanoid compounds, burmanicumols A-G (1-6) and illifrognones D-G (7-10), and seven known prenylated phenylpropanoid compounds, were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined on the basis of 1D and 2D NMR, HRESIMS, and CD experiments. Compounds 3, 8, 10, and 14 were moderately potent inhibitors of the NF-κB pathway, with IC50 values ranging from 10.31 to 35.16μg/mL tripterygium glycosides and pavlin were used as the positive controls.
从缅甸八角的茎皮中分离出10种新的异戊烯基化苯丙素类化合物，即缅甸八角醇A - G（1 - 6）和异八角酮D - G（7 - 10），以及7种已知的异戊烯基化苯丙素类化合物。通过一维和二维核磁共振、高分辨电喷雾电离质谱（HRESIMS）和圆二色（CD）实验确定了新化合物的结构。化合物3、8、10和14是NF-κB途径的中度有效抑制剂，IC50值在10.31至35.16μg/mL之间，雷公藤多苷和白芍总苷用作阳性对照。
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