一种从地枫皮（Illicium difengpi K.I.B. et K.I.M.）茎皮中分离得到的新芳香糖苷

A new aromatic glucoside from stem bark of Illicium difengpi K.I.B. et K.I.M.

作者信息

Li Chuntong, Wu Zhijun, Chen Wansheng

机构信息

a Department of Pharmacy and Pharmacology , First Affiliated Hospital of PLA General Hospital , Beijing 100048 , P.R. China.

出版信息

Nat Prod Res. 2015;29(19):1793-7. doi: 10.1080/14786419.2015.1004675. Epub 2015 Feb 3.

DOI:10.1080/14786419.2015.1004675

PMID:25647397

Abstract

A new aromatic glucoside, namely 4-methoxyphenyl-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (1), together with six known aromatic glucosides (2-7) were isolated from the stem bark of Illicium difengpi. The structures of these compounds were established by spectroscopic methods. The isolated aromatic glucosides were tested for anti-inflammatory activity. Compounds 1, 3 and 6 showed significant inhibitory effect on nuclear factor kappa B (NF-κB) in RAW 264.7 macrophages induced by lipopolysaccharide.

摘要

从地枫皮的茎皮中分离出一种新的芳香糖苷，即4-甲氧基苯基-(6-脱氧-α-L-甘露吡喃糖基)-β-D-吡喃葡萄糖苷(1)，以及六种已知的芳香糖苷(2-7)。通过光谱方法确定了这些化合物的结构。对分离得到的芳香糖苷进行了抗炎活性测试。化合物1、3和6对脂多糖诱导的RAW 264.7巨噬细胞中的核因子κB(NF-κB)具有显著的抑制作用。