Owczarczyk-Saczonek Agnieszka B, Nowicki Roman J
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland. Head of the Department: Prof. Waldemar Placek MD, PhD.
Department of Dermatology, Venereology and Allergology, Gdansk Medical University, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
Postepy Dermatol Alergol. 2015 Aug;32(4):290-5. doi: 10.5114/pdia.2014.40966. Epub 2015 Aug 12.
Some studies show that metabolic syndrome (MS) is more common in psoriatic patients.
To evaluate the prevalence of MS and its components as cardiovascular disease (CVD) risk factors in psoriatic patients compared to the general Polish population.
In 62 patients, aged 30 to 49 years with a mild to severe course of psoriasis, the features of MS have been assessed by IDF definition and compared to the results obtained in the NATPOL 2011 study.
Analysis of CVD risk factors in patients with a severe course of psoriasis showed a correlation with waist circumference (0.38, p < 0.05), hypertension (0.40, p < 0.05) and a negative correlation with HDL (0.29, p < 0.05). The prevalence of MS in psoriatic patients was 25.81%, and for the control group - 21.02% (p > 0.05), the mean HOMA-IR was 1.93 and 1.94 (p > 0.05), respectively. There were differences in the prevalence of abdominal obesity (53.6% vs. 40.3%, p < 0.05). In lipid parameters, except for HDL, the compared groups did not differ significantly (triglycerides, ApoA-I and B). Criteria for MS concerning blood pressure (> 130/85 mm Hg) and hypertension were more frequent in men with psoriasis than in the control group (38.2% vs. 11.1%, p < 0.05).
Severe psoriasis is associated with a significantly higher prevalence of risk factors for CVD. The prevalence of MS, insulin resistance and lipid abnormalities in patients with psoriasis aged 30 to 49 years is similar to the general Polish population. Abdominal obesity is more common in psoriatic patients and hypertension in men with psoriasis.
一些研究表明，代谢综合征（MS）在银屑病患者中更为常见。
评估银屑病患者中MS及其作为心血管疾病（CVD）危险因素的组成部分的患病率，并与波兰普通人群进行比较。
对62例年龄在30至49岁、银屑病病情为轻度至重度的患者，根据国际糖尿病联盟（IDF）定义评估MS特征，并与2011年波兰全国营养与健康调查（NATPOL 2011）研究结果进行比较。
对重度银屑病患者的CVD危险因素分析显示，与腰围（0.38，p<0.05）、高血压（0.40，p<0.05）呈正相关，与高密度脂蛋白（HDL）呈负相关（0.29，p<0.05）。银屑病患者中MS的患病率为25.81%，对照组为21.02%（p>0.05），平均胰岛素抵抗指数（HOMA-IR）分别为1.93和1.94（p>0.05）。腹部肥胖的患病率存在差异（53.6%对40.3%，p<0.05）。在血脂参数方面，除HDL外，比较组之间无显著差异（甘油三酯、载脂蛋白A-I和B）。银屑病男性患者中符合MS的血压标准（>130/85 mmHg）和高血压的比例高于对照组（38.2%对11.1%，p<0.05）。
重度银屑病与CVD危险因素的患病率显著较高相关。30至49岁银屑病患者中MS、胰岛素抵抗和脂质异常的患病率与波兰普通人群相似。腹部肥胖在银屑病患者中更为常见，而银屑病男性患者中高血压更为常见。
