通过泛素化对刺猬信号通路的调控。
Regulation of Hedgehog signaling by ubiquitination.
作者信息
Hsia Elaine Y C, Gui Yirui, Zheng Xiaoyan
机构信息
Department of Anatomy and Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
出版信息
Front Biol (Beijing). 2015 Jun;10(3):203-220. doi: 10.1007/s11515-015-1343-5.
Abstract
The Hedgehog (Hh) signaling pathway plays crucial roles both in embryonic development and in adult stem cell function. The timing, duration and location of Hh signaling activity need to be tightly controlled. Abnormalities of Hh signal transduction lead to birth defects or malignant tumors. Recent data point to ubiquitination-related posttranslational modifications of several key Hh pathway components as an important mechanism of regulation of the Hh pathway. Here we review how ubiquitination regulates the localization, stability and activity of the key Hh signaling components.
摘要
刺猬信号通路（Hh）在胚胎发育和成人干细胞功能中均发挥着关键作用。Hh信号活性的时间、持续时间和位置需要受到严格控制。Hh信号转导异常会导致出生缺陷或恶性肿瘤。近期数据表明，几种关键Hh信号通路组分的泛素化相关翻译后修饰是调控Hh信号通路的重要机制。在此，我们综述泛素化如何调控关键Hh信号组分的定位、稳定性及活性。
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