增生性椎间盘差异调节刺猬信号通路的转录输出。
Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.
作者信息
Wang Guolun, Tang Xiaofang, Chen Yujie, Cao Jun, Huang Qinzhu, Ling Xuemei, Ren Wenyan, Liu Songqing, Wu Yihui, Ray Lorraine, Lin Xinhua
机构信息
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China.
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
出版信息
Mech Dev. 2014 Aug;133:117-25. doi: 10.1016/j.mod.2014.05.002. Epub 2014 May 20.
Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters.
刺猬蛋白（Hh）作为一种形态发生素，通过其下游效应因子间断翅脉（Ci）激活多种靶基因的转录。目前，对于Ci如何招募辅助因子来激活转录了解较少。在此我们报告，E3泛素连接酶增生性盘（hyd）可差异性调节Hh信号的转录输出。我们发现Hyd活性缺失导致部分而非全部Hh靶基因上调。重要的是，Hyd不影响Ci的稳定性。我们的数据表明，Hyd通过与各自启动子的选择性结合来差异性抑制Ci的转录活性。
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