McDevitt-Murphy Meghan E, Parra Gilbert R, Grilo Carlos M, McGlashan Thomas H, Skodol Andrew E, Shea M Tracie, Yen Shirley, Sanislow Charles A, Gunderson John G, Markowitz John C
Department of Psychology, The University of Memphis.
Department of Psychiatry, Yale University School of Medicine.
Psychol Trauma. 2009 Dec;1(4):269-281. doi: 10.1037/a0017831.
This study investigated the co-occurrence of posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) in a sample ( = 668) recruited for personality disorders and followed longitudinally as part of the Collaborative Longitudinal Personality Disorders Study. The study both examined rates of co-occurring disorders at baseline and temporal relationships between PTSD and substance use disorders over 4 years. Subjects with a lifetime history of PTSD at baseline had significantly higher rates of SUDs (both alcohol and drug) than subjects without PTSD. Latent class growth analysis, a relatively novel approach used to analyze trajectories and identify homogeneous subgroups of participant on the basis of probabilities of PTSD and SUD over time, identified 6 classes, which were compared with respect to a set of functioning and personality variables. The most consistent differences were observed between the group that displayed low probabilities of both SUD and PTSD and the group that displayed high probabilities of both.
本研究在一个为研究人格障碍而招募的样本（n = 668）中调查了创伤后应激障碍（PTSD）和物质使用障碍（SUDs）的共病情况，并作为协作纵向人格障碍研究的一部分进行了纵向跟踪。该研究既考察了基线时共病障碍的发生率，也考察了4年期间PTSD与物质使用障碍之间的时间关系。基线时有PTSD终生史的受试者的SUDs（包括酒精和药物）发生率显著高于无PTSD的受试者。潜在类别增长分析是一种相对新颖的方法，用于分析轨迹并根据PTSD和SUD随时间变化的概率识别参与者的同质亚组，该分析确定了6个类别，并就一组功能和人格变量对这些类别进行了比较。在SUD和PTSD概率均较低的组与两者概率均较高的组之间观察到了最一致的差异。
