Poljacki M, Stojanović S, Svilar V
Med Pregl. 1989;42(3-4):149-51.
The results of the local application of 5-fluorouracil in the form of cream ("Efudix" Roche) in the therapy of senile keratoses and basocellular carcinomas were presented in this paper. A total of 205 changes of senile keratoses and 27 changes of basocellular carcinomas were treated in 90 patients. The cream was put on changes of senile keratoses without covering two times daily during a three--week period on the average up to the appearance of erosion. In cases of basaloma the cream was administered in the form of occlusive bandage with the duration of six hours each day. The treatment was undertaken until the appearance of ulceration and lasted three weeks. In all treated cases after the appearance of erosion and ulceration cream for epithelization was applied in further therapy. Out of all 232 treated changes either of senile keratosis or basaloma, successful treatment was attained in 230 (99.15%) cases and in only 2 cases of nodous basaloma successful treatment was not attained which accounted for 0.85% of treated lesions. Cosmetic results of the treatment were excellent. The appearance of relapse was not observed in any case during a three--year period.
本文介绍了以乳膏形式（“艾氟迪”，罗氏公司）局部应用5-氟尿嘧啶治疗老年角化病和基底细胞癌的结果。90例患者共治疗了205处老年角化病病变和27处基底细胞癌病变。乳膏涂抹于老年角化病病变处，不覆盖，平均每天两次，持续三周，直至出现糜烂。对于基底细胞瘤，乳膏采用封闭绷带形式给药，每天持续6小时。治疗持续进行直至出现溃疡，持续三周。在所有治疗病例中，出现糜烂和溃疡后，在后续治疗中应用促进上皮化的乳膏。在所有232处接受治疗的老年角化病或基底细胞瘤病变中，230例（99.15%）治疗成功，仅2例结节性基底细胞瘤治疗未成功，占治疗病变的0.85%。治疗的美容效果极佳。在三年期间未观察到任何复发情况。
