Dillaha C J, Jansen G T, Honeycutt W M, Bradford A C
Arch Dermatol. 1983 Sep;119(9):774-83.
As an investigative procedure, a hydrophilic ointment containing 20% 5-fluorouracil (5-FU) was applied to the skin of patients with extensive actinic keratoses of the face and neck, for a period of four weeks. This resulted in a selective inflammation, erosion, and disappearance of the keratoses without significant alteration of the normal skin. Transitory adverse reactions included corneal and conjunctival irritations, phototoxic reactions, and erosion of the lower lip border. No evidence of systemic absorption was detected. Only preliminary follow-up observations are available, and no conclusion can be drawn as to the long-term results.
作为一种研究性程序，一种含有20% 5-氟尿嘧啶（5-FU）的亲水性软膏被应用于面部和颈部患有广泛性光化性角化病的患者皮肤，为期四周。这导致了角化病的选择性炎症、糜烂和消失，而正常皮肤无明显改变。短暂的不良反应包括角膜和结膜刺激、光毒性反应以及下唇边缘糜烂。未检测到全身吸收的证据。仅可获得初步的随访观察结果，关于长期结果无法得出结论。
