Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13302-6. doi: 10.1002/anie.201507134. Epub 2015 Sep 14.
Flavones are a class of natural products with diverse biological activities and have frequently been synthesized by step-by-step procedures using stoichiometric amounts of reagents. Herein, a catalytic one-pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on a Mg-Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2'-hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one-pot procedure consists of a sequence of several reactions, and Au/LDH can catalyze all these different types of reactions. The catalysis is shown to be truly heterogeneous, and Au/LDH can be readily recovered and reused.
黄酮类化合物是一类具有多种生物活性的天然产物，通常采用逐步合成的方法，使用化学计量的试剂进行合成。在此，开发了一种催化一锅法合成黄酮及其衍生物的方法。在负载于 Mg-Al 层状双氢氧化物（Au/LDH）上的金纳米粒子的存在下，可从 2'-羟基苯乙酮和苯甲醛（或苄醇）出发合成各种黄酮类化合物。该一锅法反应包括一系列的反应，Au/LDH 可以催化所有这些不同类型的反应。该催化反应是真正的多相催化，Au/LDH 可以很容易地回收和重复使用。
